Gp78 E3泛素连接酶：蛋白质稳态的基本功能和贡献。,Frontiers in Cellular Neuroscience

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Gp78 E3泛素连接酶：蛋白质稳态的基本功能和贡献。
Frontiers in Cellular Neuroscience ( IF 4.2 ) Pub Date : 2017-09-12 , DOI: 10.3389/fncel.2017.00259
Vibhuti Joshi ₁ , Arun Upadhyay ₁ , Amit Kumar ₂ , Amit Mishra ₁

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根据新陈代谢和适应性的要求，正常的细胞功能由几种蛋白质控制，并且它们的相互作用分子和信号事件处于多个水平。蛋白质质量控制（PQC）机制可确保正确折叠和正确利用这些蛋白质，以避免其错误折叠和聚集。为了维持复杂蛋白质组的最佳环境，PQC系统使用各种E3泛素连接酶选择性降解异常蛋白。糖蛋白78（Gp78）是一种E3泛素连接酶，可通过内质网相关降解（ERAD）防止不同折叠错误的蛋白质的多因素有害积累。但是，尚不清楚在应激条件下Gp78在避免大量错误折叠的聚集中的确切作用，它可以作为建立蛋白质组动态性质的关键资源。本文系统地解释了Gp78的详细分子特征，还介绍了其各种细胞生理功能，这对实现蛋白质稳态至关重要。在这里，我们全面介绍了Gp78的最新发现，显示了其在不同生理功能和疾病中的PQC作用。从而提出了新的机会，以更好地理解与不同蛋白质错误折叠障碍有关的治疗性干预措施尚未解决的问题。我们全面代表了Gp78的最新发现，表明了其在不同生理功能和疾病中的PQC作用；从而提出了新的机会，以更好地理解与不同蛋白质错误折叠障碍有关的治疗性干预措施尚未解决的问题。我们全面代表了Gp78的最新发现，表明了其在不同生理功能和疾病中的PQC作用；从而提出了新的机会，以更好地理解与不同蛋白质错误折叠障碍有关的治疗性干预措施尚未解决的问题。

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Gp78 E3 Ubiquitin Ligase: Essential Functions and Contributions in Proteostasis.

As per the requirement of metabolism and fitness, normal cellular functions are controlled by several proteins, and their interactive molecular and signaling events at multiple levels. Protein quality control (PQC) mechanisms ensure the correct folding and proper utilization of these proteins to avoid their misfolding and aggregation. To maintain the optimum environment of complex proteome PQC system employs various E3 ubiquitin ligases for the selective degradation of aberrant proteins. Glycoprotein 78 (Gp78) is an E3 ubiquitin ligase that prevents multifactorial deleterious accumulation of different misfolded proteins via endoplasmic reticulum-associated degradation (ERAD). However, the precise role of Gp78 under stress conditions to avoid bulk misfolded aggregation is unclear, which can act as a crucial resource to establish the dynamic nature of the proteome. Present article systematically explains the detailed molecular characterization of Gp78 and also addresses its various cellular physiological functions, which could be crucial to achieving protein homeostasis. Here, we comprehensively represent the current findings of Gp78, which shows its PQC roles in different physiological functions and diseases; and thereby propose novel opportunities to better understand the unsolved questions for therapeutic interventions linked with different protein misfolding disorders.

更新日期：2019-11-01

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