We present an overview of quantitative and label-free optical methods used to characterize living biological tissues, with an emphasis on emerging applications in clinical tissue diagnostics. Specifically, this review focuses on diffuse optical spectroscopy, imaging, and tomography, optical coherence-based techniques, and non-linear optical methods for molecular imaging. The potential for non- or minimally-invasive assessment, quantitative diagnostics, and continuous monitoring enabled by these tissue-optics technologies provides significant promise for continued clinical translation.

中文翻译：

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在活体人体组织中进行定量和无标记传感的光学方法：原理、技术和应用。


我们概述了用于表征活体生物组织的定量和无标记光学方法，重点是临床组织诊断中的新兴应用。具体来说，本综述重点关注漫反射光谱、成像和断层扫描、基于光学相干的技术以及分子成像的非线性光学方法。这些组织光学技术所实现的无创或微创评估、定量诊断和连续监测的潜力为持续的临床转化提供了重要的希望。