<br>肾素-血管紧张素-醛固酮（RAAS）：无处不在的体内平衡和病理系统,Biomedicine & Pharmacotherapy

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肾素-血管紧张素-醛固酮（RAAS）：无处不在的体内平衡和病理系统
Biomedicine & Pharmacotherapy ( IF 6.9 ) Pub Date : 2017-07-31 , DOI: 10.1016/j.biopha.2017.07.091
Seema Patel ₁ , Abdur Rauf ₂ , Haroon Khan ₃ , Tareq Abu-Izneid ₄

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肾素-血管紧张素-醛固酮系统（RAAS）是人体的重要系统，因为它维持血浆钠浓度、动脉血压和细胞外体积。肾脏分泌的肾素酶作用于其底物，形成血管紧张素 II，这是一种多功能效应肽激素。每个器官都受到 RAAS 激活以及由此产生的高血压、细胞增殖、炎症和纤维化的影响。肾素和血管紧张素 II 的失衡会导致大量的慢性和急性疾病。RAAS 受其他酶、激素、泵和信号通路的影响，因此，本文讨论了该系统的重要方面，以及它与其他关键因素（如雌激素、甲状腺、皮质醇、激肽释放酶-激肽系统、Wnt/β-catenin 信号传导和钠钾泵）的串扰。RAAS 与上述系统的联系之前曾被粗略地探讨过。因此，这篇综述为理解炎症性疾病提供了新的视角。接下来是假设的形成，这有助于更好地管理困扰人类的一系列病症。通过使其向 ACE2 表达弯曲来操纵 RAAS 可以调节内分泌功能，这对于许多病理管理至关重要。饮食干预可以使 RAAS 恢复正常。

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Renin-angiotensin-aldosterone (RAAS): The ubiquitous system for homeostasis and pathologies

Renin-angiotensin-aldosterone system (RAAS) is a vital system of human body, as it maintains plasma sodium concentration, arterial blood pressure and extracellular volume. Kidney-secreted renin enzyme acts on its substrate to form angiotensin II, a versatile effector peptide hormone. Every organ is affected by RAAS activation and the resultant hypertension, cell proliferation, inflammation, and fibrosis. The imbalance of renin and angiotensin II can result in an overwhelming number of chronic and acute diseases. RAAS is influenced by other enzymes, hormones, pumps and signaling pathways, hence, this review discusses important facets of this system, its crosstalk with other crucial factors like estrogen, thyroid, cortisol, kallikrein-kinin system, Wnt/β-catenin signaling, and sodium-potassium pump. The nexus of RAAS with the above-discussed systems was scantily explored before. So, this review furnishes a new perspective in comprehension of inflammation diseases. It is followed by the formulation of hypotheses, which can contribute to better management of an array of pathologies plaguing mankind. Manipulation of RAAS, by bending it towards ACE2 expression can regulate endocrine functions, which can be critical for a number of pathological management. Dietary intervention can restore RAAS to normalcy.

更新日期：2017-07-31

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