Imidazo[1,2-a]pyridines play an important role in medicinal chemistry. In spite of very drastic developments on syntheses and functionalization in this area, the use of inexpensive catalysts and mild reaction conditions constitutes an important role in pharmaceutical applications. This account describes our recent efforts on the development of new methods for the synthesis of imidazo[1,2-a]pyridines using readily available starting substrates and catalysts under very mild reaction conditions. In the direction of enhancement of biological activity, we also described the synthesis of functionalized imidazo [1,2-a]pyridine derivatives.

中文翻译：

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咪唑并[1,2-a]吡啶的合成：沿CS键形成方向的CH官能化。

咪唑并[1,2-a]吡啶在药物化学中起重要作用。尽管该领域在合成和功能化方面取得了非常大的发展，但廉价的催化剂的使用和温和的反应条件仍在药物应用中起着重要的作用。该描述描述了我们最近在开发非常新的方法上的努力，该新方法使用易得的起始底物和催化剂在非常温和的反应条件下合成咪唑并[1,2-a]吡啶。在增强生物活性的方向上，我们还描述了功能化的咪唑并[1,2-a]吡啶衍生物的合成。