<br>通过 TAT 靶向固体脂质纳米颗粒共同递送紫杉醇和 TOS-顺铂，对宫颈癌具有协同抗肿瘤活性。,International Journal of Nanomedicine

当前位置： X-MOL 学术 › Int. J. Nanomed. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

通过 TAT 靶向固体脂质纳米颗粒共同递送紫杉醇和 TOS-顺铂，对宫颈癌具有协同抗肿瘤活性。
International Journal of Nanomedicine ( IF 6.6 ) Pub Date : 2017-01-31 , DOI: 10.2147/ijn.s115136
Bo Liu ₁ , Li Han ₁ , Junyan Liu ₁ , Shumei Han ₁ , Zhen Chen ₁ , Lixi Jiang ₁

Affiliation

背景技术宫颈癌是女性的一个主要的世界健康问题。目前，癌症研究的重点是使用各种治疗方案改善宫颈癌的治疗，例如通过纳米载体共同递送化疗药物。目的本研究的目的是开发反式激活转录激活剂（TAT）修饰的固体脂质纳米颗粒（SLN），用于共同递送紫杉醇（PTX）和α-生育酚琥珀酸酯-顺铂前药（TOS-CDDP）（TAT PTX） /TOS-CDDP SLNs）以实现针对宫颈癌的协同抗肿瘤活性。方法合成CDDP脂质前药(TOS-CDDP)和含TAT的聚乙二醇二硬脂酰磷脂酰乙醇胺(TAT-PEG-DSPE)。采用乳化和溶剂蒸发法制备 TAT PTX/TOS-CDDP SLN。探索了 SLN 的物理化学特征，例如尺寸、形态和释放曲线。进行了体外和体内研究以评估其在靶细胞中的抗肿瘤活性的功效。结果 TAT PTX/TOS-CDDP SLNs 可以成功地被 HeLa 细胞内化，并在抑制宫颈肿瘤细胞生长方面表现出协同作用。它们表现出高肿瘤组织积累、优异的抗肿瘤效率和低得多的体内毒性。结论本研究表明，共递送系统为治疗宫颈癌以及可能还有其他类型的癌症的联合疗法提供了一个有前途的平台。

"点击查看英文标题和摘要"

Co-delivery of paclitaxel and TOS-cisplatin via TAT-targeted solid lipid nanoparticles with synergistic antitumor activity against cervical cancer.

BACKGROUND Cervical cancer is a major world health problem for women. Currently, cancer research focuses on improving therapy for cervical cancer using various treatment options such as co-delivery of chemotherapeutic agents by nanocarriers. PURPOSE The aim of this study was to develop trans-activating transcriptional activator (TAT)-modified solid lipid nanoparticles (SLNs) for co-delivery of paclitaxel (PTX) and α-tocopherol succinate-cisplatin prodrug (TOS-CDDP) (TAT PTX/TOS-CDDP SLNs) in order to achieve synergistic antitumor activity against cervical cancer. METHODS Lipid prodrug of CDDP (TOS-CDDP) and TAT-containing polyethylene glycol-distearoyl-phosphatidylethanolamine (TAT-PEG-DSPE) were synthesized. TAT PTX/TOS-CDDP SLNs were prepared by emulsification and solvent evaporation method. Physicochemical characteristics of SLNs such as size, morphology, and release profiles were explored. In vitro and in vivo studies were carried out to assess the efficacy of their antitumor activity in target cells. RESULTS TAT PTX/TOS-CDDP SLNs could be successfully internalized by HeLa cells and showed a synergistic effect in the suppression of cervical tumor cell growth. They exhibited high tumor tissue accumulation, superior antitumor efficiency, and much lower toxicity in vivo. CONCLUSION The present study indicates that the co-delivery system provides a promising platform as a combination therapy for the treatment of cervical cancer, and possibly other types of cancer as well.

更新日期：2019-11-01

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文本刊介绍/投稿指南