To observe the biological characteristic and the prognoses in patients with acute erythroleukemia (AEL). The results of 167 patients with newly diagnosed AEL, from January 2004 and June 2014 in the department of Hematology, Shandong Province Chinese Medicine Hospital, were reviewed by morphology, immunology, cytogenetics, molecular biology. Flow cytometry analysis indicated that CD13 (96.1 %), CD33 (95.1 %), CD117 (87.4 %) and CD34 (79.4 %) were highly expressed in AEL. 56 of 148 (37.8 %) AEL patients had a variety of cytogenetic abnormalities, 27 of 148 (18.2 %) patients were complex karyotype (abnormal involving 3 or more chromosomes), the abnormalities of chromosomes 3, 5, 7 and 8 were more frequently involved and the most common one was +8, accounting for 35.7 % of all abnormal karyotype, followed by 5q- (17.9 %). Mutation analysis showed CEBPA mutation ratio of AEL patients was 44.0 % (11/25), that of NPM1as 15.4 % (4/26). Initial induced remission rate of AEL was 56.6 % (30/53), compared by 33.3 % (4/12) of MDSM6. Survival analysis was shown that the overall survival in female was better than that in male (P = 0.047). The overall survival time of transplantation group was significantly longer than chemotherapy group (P = 0.000). The OS of 13-39 years old group was the best, 40-49 years old group took second place, >50 years old group appeared to be the worst. Patients with AML-M6 had dysplasia in varying degrees in granulocyte, erythrocyte and megakaryocyte series. Periodic acid-Shiff reaction staining in polychromatic erythroblast and ortho-chromatic erythroblast had a specificity in the diagnosis of AEL. AEL had its own unique biological features, and allogeneic hematopoietic stem cell transplantation could significantly improve its poor prognosis.

中文翻译：

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急性红细胞白血病167例的临床特点及预后。

观察急性红白血病（AEL）患者的生物学特征和预后。分别于2004年1月至2014年6月在山东省中医院血液科对167例新诊断为AEL的患者进行了形态，免疫学，细胞遗传学，分子生物学研究。流式细胞仪分析表明，CD13（96.1％），CD33（95.1％），CD117（87.4％）和CD34（79.4％）在AEL中高度表达。148名AEL患者中的56名（37.8％）具有多种细胞遗传学异常，148名患者中27名（18.2％）为复杂核型（涉及3个或更多染色体的异常），3、5、7和8号染色体异常的发生频率更高其中最常见的是+8，占所有异常核型的35.7％，其次是5q-（17.9％）。突变分析显示，AEL患者的CEBPA突变率为44.0％（11/25），而NPM1的CEBPA突变率为15.4％（4/26）。初始诱发的AEL缓解率为56.6％（30/53），而MDSM6为33.3％（4/12）。生存分析表明，女性的总生存率优于男性（P = 0.047）。移植组的总生存时间明显长于化疗组（P = 0.000）。13-39岁组的OS最好，40-49岁组的OS排名第二，> 50岁组的OS最差。AML-M6患者的粒细胞，红细胞和巨核细胞系列均有不同程度的异型增生。多色红细胞和正色红细胞中的高碘酸-希夫反应染色对AEL的诊断具有特异性。AEL具有自己独特的生物学特征，