Deep brain stimulation (DBS) is a surgical option for advanced Parkinson's disease. Although DBS is used to treat motor fluctuation, DBS may affect non-motor symptoms including mood disorders, cognitive dysfunction, and behavior problems. Impulse control disorders (ICDs) are abnormal behaviors with various manifestations such as pathological gambling, hypersexuality, compulsive shopping, and binge eating, which can affect the quality of life in patients with Parkinson's disease. The effect of DBS on ICD is controversial. Reducing medication by DBS may improve ICDs, however, worsening or even developing new ICDs after DBS can occur. We will review the impact of DBS on ICDs and reveal factors associated with a good response to DBS as well as risk factors for developing ICDs after DBS. We also propose a strategy to manage preexisting ICD and prevent postoperative de novo ICDs.

中文翻译：

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用深部脑刺激治疗冲动控制障碍：一把双刃剑

深部脑刺激 (DBS) 是晚期帕金森病的一种手术选择。虽然 DBS 用于治疗运动波动，但 DBS 可能会影响非运动症状，包括情绪障碍、认知功能障碍和行为问题。冲动控制障碍（ICDs）是一种具有病理性赌博、性欲亢进、强迫性购物、暴饮暴食等多种表现的异常行为，可影响帕金森病患者的生活质量。DBS 对 ICD 的影响是有争议的。通过 DBS 减少药物治疗可能会改善 ICD，但是，DBS 后可能会恶化甚至开发新的 ICD。我们将回顾 DBS 对 ICD 的影响，并揭示与 DBS 良好反应相关的因素以及 DBS 后发展 ICD 的风险因素。