ABSTRACT Introduction: WY14643 – also known as pirinixic acid – is a versatile fatty acid mimetic that was originally developed as lipid lowering agent without knowledge of its molecular target. Various later studies discovered somewhat promiscuous activity of the compound on several receptors and enzymes. Pirinixic acid though never having reached clinical use was subjected to many in vivo studies and exerted beneficial effects in a variety of disease models. Areas covered: Inventions claiming the use of WY14643 for numerous indications ranging from the originally intended application in metabolic dysbalances over cancer and inflammation to some rare syndromes have been evaluated. Expert opinion: It is rather unlikely that pirinixic acid will gain relevance in treatment of metabolic diseases for which it was originally developed because more efficient and selective alternatives are available. Instead, several other claimed activities of the compound e.g. in inflammation, neurodegeneration and cancer seem very promising. However, some of the underlying studies are biased and for some effects of pirinixic acid, the molecular target and mode of action remain to be identified.

中文翻译：

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多功能脂肪酸模拟物 WY14643 的治疗应用

摘要 介绍： WY14643 - 也称为pirinixic 酸 - 是一种多功能的脂肪酸模拟物，最初是作为降脂剂开发的，但不知道其分子靶点。后来的各种研究发现该化合物对几种受体和酶的活性有些混杂。Pirinixic 酸虽然从未达到临床用途，但已进行了许多体内研究，并在各种疾病模型中发挥了有益作用。涵盖的领域： 声称将 WY14643 用于多种适应症的发明已经过评估，范围从最初用于治疗癌症和炎症引起的代谢失衡到一些罕见的综合征。专家意见：pirinixic 酸不太可能在治疗代谢疾病中获得相关性，因为有更有效和选择性的替代品可供使用。相反，该化合物的其他几种声称的活性，例如在炎症、神经变性和癌症方面，似乎很有希望。然而，一些基础研究是有偏见的，对于pirinixic酸的某些作用，分子靶点和作用方式仍有待确定。