晚期糖基化终产物的可溶性受体 (sRAGE) 和 S100A12 (EN-RAGE) 与长期血液透析患者死亡率之间的关联,Journal of Korean Medical Science

当前位置： X-MOL 学术 › J. Korean Med. Sci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

晚期糖基化终产物的可溶性受体 (sRAGE) 和 S100A12 (EN-RAGE) 与长期血液透析患者死亡率之间的关联
Journal of Korean Medical Science ( IF 3.0 ) Pub Date : 2017-01-01 , DOI: 10.3346/jkms.2017.32.1.54
Eul Sik Jung ₁ , Wookyung Chung _{1,

2} , Ae Jin Kim _{1,

2} , Han Ro _{1,

2} , Jae Hyun Chang _{1,

2} , Hyun Hee Lee _{1,

2} , Ji Yong Jung _{1,

2}

Affiliation

血液透析 (HD) 患者会出现血管钙化，最终导致高死亡率。以前，我们报道了晚期糖基化终产物 (sRAGE) 的可溶性受体与细胞外新发现的 RAGE 结合蛋白 S100A12 (EN-RAGE) 和血管钙化之间的关联。在这里，我们扩展了我们的观察，研究这些生物标志物是否可用于预测这些受试者的心血管发病率和死亡率。因此，我们评估了 sRAGE 和 S100A12 与长期 HD 患者死亡率之间的关系。这是一项前瞻性观察队列研究，对 199 名 HD 患者进行了对我们之前研究的扩展分析。研究了血浆 sRAGE、S100A12、合并症和其他传统危险因素。在多变量分析中评估了使用 Cox 比例风险回归的累积死亡发生率。观察期为44个月。在观察期间，27（13.6%）名患者死亡。单变量分析表明，S100A12 与糖尿病（P = 0.040）和高敏 C 反应蛋白（hsCRP）（P = 0.006）相关。在多变量分析中，血浆 sRAGE（风险比 [HR] = 1.155；95% 置信区间 [CI] = 0.612–2.183；P = 0.656）和 S100A12（HR = 0.960；95% CI = 0.566–1.60.8；P与 HD 患者的死亡率无关，尽管传统的死亡率预测因素，包括年龄、心血管疾病 (CVD) 史以及血清白蛋白和 hsCRP 水平与死亡率相关。死亡率的有力预测因素是年龄、心血管疾病和白蛋白水平。

"点击查看英文标题和摘要"

Associations between Soluble Receptor for Advanced Glycation End Products (sRAGE) and S100A12 (EN-RAGE) with Mortality in Long-term Hemodialysis Patients

Hemodialysis (HD) patients experience vascular calcification, ultimately leading to high mortality rates. Previously, we reported associations between soluble receptor for advanced glycation end products (sRAGEs) and extracellular newly identified RAGE-binding protein S100A12 (EN-RAGE) and vascular calcification. Here, we extended our observations, investigating whether these biomarkers may be useful for predicting cardiovascular morbidity and mortality in these subjects. Thus, we evaluated the relationship between sRAGE and S100A12 and mortality in long-term HD patients. This was a prospective observational cohort study in 199 HD patients from an extended analysis of our previous study. Plasma sRAGE, S100A12, comorbidities, and other traditional risk factors were investigated. The cumulative incidences for death using Cox proportional hazards regression were evaluated in multivariable analyses. The observation period was 44 months. During the observation period, 27 (13.6%) patients died. Univariate analysis demonstrated that S100A12 was correlated with diabetes (P = 0.040) and high-sensitivity C-reactive protein (hsCRP) (P = 0.006). In multivariable analyses, plasma sRAGE (hazard ratio [HR] = 1.155; 95% confidence interval [CI] = 0.612–2.183; P = 0.656) and S100A12 (HR = 0.960; 95% CI = 0.566–1.630; P = 0.881) were not associated with mortality in HD patients, although traditional predictors of mortality, including age, history of cardiovascular diseases (CVDs), and serum levels of albumin and hsCRP were related to mortality. Powerful predictors of mortality were age, CVD, and albumin levels. Plasma sRAGE and S100A12 may be weak surrogate markers for predicting all-cause mortality in patients undergoing HD, although S100A12 was partly related to diabetes and inflammation.

更新日期：2017-01-01

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文本刊介绍/投稿指南