INTRODUCTION The aim of this study is to evaluate gatifloxacin-loaded sodium alginate hydrogel membranes, supplemented with glycerol (a plasticizer), glutaraldehyde (a cross-linking agent), and hydroxypropyl methylcellulose (HPMC) or hydroxypropyl cellulose (HPC) polymers, as potential wound dressing materials based on their physicochemical properties and the sustain-release phenomenon. MATERIALS AND METHODS The physicochemical properties of the prepared hydrogel membranes were evaluated by several methods including Fourier transform infrared and differential scanning calorimetry. Different techniques were used to assess the swelling behavior, tensile strength and elongation, % moisture absorption, % moisture loss, water vapor transmission rate (WVTR), and microbial penetration for the hydrogel membranes. In vitro gatifloxacin release from the hydrogel membranes was examined using the United States Pharmacopeia XXIII dissolution apparatus. Four kinetics models (zero-order, first-order, Higuchi equation, and Korsmeyer-Peppas equation) were applied to study drug release kinetics. RESULTS The addition of glycerol, glutaraldehyde, HPMC, and HPC polymers resulted in a considerable increase in the tensile strength and flexibility/elasticity of the hydrogel membranes. WVTR results suggest that hydrated hydrogel membranes can facilitate water vapor transfer. None of the hydrogel membranes supported microbial growth. HPMC-treated and HPC-treated hydrogel membranes allow slow, but sustained, release of gatifloxacin for 48 h. Drug release kinetics revealed that both diffusion and dissolution play an important role in gatifloxacin release. CONCLUSIONS Given their physicochemical properties and gatifloxacin release pattern, HPMC-treated and HPC-treated hydrogel membranes exhibit effective and sustained drug release. Furthermore, HPMC-treated and HPC-treated hydrogel membranes possess physiochemical properties that make them effective and safe wound dressing materials.

中文翻译：

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载有加替沙星的海藻酸钠水凝胶膜的制备和表征，辅以羟丙基甲基纤维素和羟丙基纤维素聚合物，用于伤口包扎。

引言这项研究的目的是评估加替沙星负载的藻酸钠水凝胶膜，并补充甘油（一种增塑剂），戊二醛（一种交联剂）和羟丙基甲基纤维素（HPMC）或羟丙基纤维素（HPC）聚合物。基于其理化性质和持续释放现象的伤口敷料。材料与方法通过傅立叶变换红外和差示扫描量热法等多种方法对制备的水凝胶膜的理化性质进行了评估。使用不同的技术评估水凝胶膜的溶胀行为，拉伸强度和伸长率，吸湿率％，水分损失率，水蒸气透过率（WVTR）和微生物渗透率。使用美国药典XXIII溶出度仪检查了体外加替沙星从水凝胶膜中释放的情况。四个动力学模型（零阶，一阶，Higuchi方程和Korsmeyer-Peppas方程）用于研究药物释放动力学。结果添加甘油，戊二醛，HPMC和HPC聚合物导致水凝胶膜的拉伸强度和柔韧性/弹性显着提高。WVTR结果表明，水合水凝胶膜可以促进水蒸气的转移。水凝胶膜均不支持微生物生长。HPMC处理和HPC处理的水凝胶膜可使加替沙星缓慢但持续释放48小时。药物释放动力学表明，扩散和溶解在加替沙星释放中均起重要作用。结论鉴于其理化性质和加替沙星的释放模式，HPMC处理和HPC处理的水凝胶膜表现出有效且持续的药物释放。此外，HPMC处理和HPC处理的水凝胶膜具有理化特性，使其成为有效且安全的伤口敷料材料。