Ammonium, 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate has been developed as a processing aid used in the manufacture of fluoropolymers. The absorption, distribution, elimination, and distribution (ADME) and kinetic behavior of this substance has been evaluated in rats, mice, and cynomolgus monkeys by oral and intravenous routes of exposure and studied in both plasma and urine. The test substance is rapidly and completely absorbed in both rats and mice and both in vivo and in vitro experiments indicate that it is not metabolized. The test substance is rapidly eliminated exclusively in the urine in both rats and mice, with rats eliminating it more quickly than mice (approximately 5h elimination half-life in rats, 20 h half-life in mice). Pharmacokinetic analysis in monkeys, rats, and mice indicate rapid, biphasic elimination characterized by a very fast alpha phase and a slower beta phase. The beta phase does not contribute to potential accumulation after multiple dosing in rats or monkeys. Comparative pharmacokinetics in rats, mice, and monkeys indicates that the rat is more similar to the monkey and is therefore a more appropriate rodent model for pharmacokinetics in primates.

中文翻译：

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大鼠、小鼠和食蟹猴单次给药后 2,3,3,3-四氟-2-（七氟丙氧基）丙酸铵盐的吸收、分布、代谢、排泄和动力学。

2,3,3,3-四氟-2-（七氟丙氧基）-丙酸铵已被开发用作制造含氟聚合物的加工助剂。该物质的吸收、分布、消除和分布 (ADME) 和动力学行为已在大鼠、小鼠和食蟹猴中通过口服和静脉接触途径进行评估，并在血浆和尿液中进行了研究。受试物质在大鼠和小鼠中都被迅速而完全地吸收，体内和体外实验均表明它不被代谢。受试物质在大鼠和小鼠中均迅速从尿液中完全消除，大鼠比小鼠的消除速度更快（大鼠的消除半衰期约为 5 小时，小鼠的半衰期约为 20 小时）。在猴子、大鼠和小鼠中的药代动力学分析表明快速、双相消除的特点是非常快的 α 相和较慢的 β 相。在大鼠或猴子中多次给药后，β 期不会导致潜在的蓄积。大鼠、小鼠和猴子的比较药代动力学表明大鼠与猴子更相似，因此是灵长类动物药代动力学更合适的啮齿动物模型。