18-HEPE 是一种由巨噬细胞释放的 n-3 脂肪酸代谢物，可防止压力超负荷引起的适应不良心脏重塑。,Journal of Experimental Medicine

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18-HEPE 是一种由巨噬细胞释放的 n-3 脂肪酸代谢物，可防止压力超负荷引起的适应不良心脏重塑。
Journal of Experimental Medicine ( IF 12.6 ) Pub Date : 2014-07-21 , DOI: 10.1084/jem.20132011
Jin Endo ₁ , Motoaki Sano ₂ , Yosuke Isobe ₃ , Keiichi Fukuda ₂ , Jing X Kang ₄ , Hiroyuki Arai ₅ , Makoto Arita ₆

Affiliation

Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
Laboratory for Lipid Medicine and Technology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02115.
Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan

N-3 多不饱和脂肪酸 (PUFA) 具有潜在的心血管益处，尽管这种作用的潜在机制仍知之甚少。Fat-1 转基因小鼠表达秀丽隐杆线虫 n-3 脂肪酸去饱和酶，能够从 n-6 多不饱和脂肪酸产生 n-3 多不饱和脂肪酸，表现出对压力超负荷诱导的炎症和纤维化的抵抗力，以及降低的心脏功能。脂质组学分析显示，fat-1 转基因骨髓 (BM) 细胞中二十碳五烯酸 (EPA) 和 fat-1 转基因巨噬细胞中 EPA 代谢物 18-羟基二十碳五烯酸 (18-HEPE) 的选择性富集。BM 移植实验表明，fat-1 转基因 BM 细胞，但不是 fat-1 转基因心脏细胞，有助于抗重塑作用，并且 fat-1 转基因心脏中富含 18-HEPE 的环境是由 BM 衍生细胞（最有可能是巨噬细胞）产生的。18-HEPE 抑制培养中巨噬细胞介导的心脏成纤维细胞的促炎性激活，体内施用 18-HEPE 重现了 fat-1 小鼠的表型，包括对压力超负荷诱导的适应不良心脏重塑的抵抗力。

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更新日期：2019-11-01

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