OARSI骨关节炎软骨组织病理学评估系统：在人类膝盖中的生物力学评估。,Journal of Orthopaedic Research

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OARSI骨关节炎软骨组织病理学评估系统：在人类膝盖中的生物力学评估。
Journal of Orthopaedic Research ( IF 2.1 ) Pub Date : 2015-08-08 , DOI: 10.1002/jor.23010
Wenzel Waldstein ₁ , Giorgio Perino ₂ , Susannah L Gilbert ₃ , Suzanne A Maher ₃ , Reinhard Windhager ₁ , Friedrich Boettner ₄

Affiliation

该研究将OARSI骨关节炎软骨组织病理学评估系统与人体内软骨样品的生物力学质量进行了比较。在一项前瞻性队列研究中，纳入了2010年5月至2012年1月之间84例（100膝）膝内翻畸形的患者。对骨软骨样本进行了生物力学和组织学分析。从OARSI等级0（表面完好）到OARSI等级4（侵蚀）的每个退化等级，动态模量均显着降低（p <0.001）。对于总模量，OARSI 0级和OARSI 1级之间以及OARSI 1级和OARSI 2级之间存在显着（p <0.001）差异。从OARSI 2级到OARSI 5级，没有发生总模量差异。新的OARSI分级系统提供了有关软骨功能特性的有用信息。具有完整表面且无退化迹象（OARSI等级0）与具有完整表面和关节炎早期迹象（OARSI等级1）的样品之间的软骨硬度之间存在显着差异。进行关节保留手术的外科医生必须意识到，在具有完整软骨表面（OARSI 0/1级）的膝盖中，生物力学特性可能存在显着差异。

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OARSI osteoarthritis cartilage histopathology assessment system: A biomechanical evaluation in the human knee.

The study compared the OARSI osteoarthritis cartilage histopathology assessment system with the biomechanical quality of human in vivo cartilage samples. In a prospective cohort study, 84 patients (100 knees) with varus deformity of the knee were included between May, 2010 and January, 2012. Osteochondral samples underwent biomechanical and histologic analysis. The dynamic modulus significantly (p < 0.001) decreased with each advancing grade of degeneration from OARSI Grade 0 (surface intact) to OARSI Grade 4 (erosion). For the aggregate modulus, there were significant (p < 0.001) differences between OARSI Grade 0 and OARSI Grade 1 as well as between OARSI Grade 1 and OARSI Grade 2. From OARSI Grade 2 to OARSI Grade 5, no differences in aggregate modulus occurred. The new OARSI grading system provides useful information about the functional properties of cartilage. There is a significant difference in cartilage stiffness between samples with intact surface and no signs of degeneration (OARSI Grade 0) and samples with intact surface and early signs of arthritis (OARSI Grade 1). Surgeons performing joint preserving procedures have to be aware that in knees with an intact cartilage surface (OARSI Grade 0/1), significant differences in the biomechanical properties may exist.

更新日期：2019-11-01

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