Total Synthesis of (+)-Conolidine by the Gold(I)-Catalyzed Cascade Cyclization of a Conjugated Enyne,The Journal of Organic Chemistry

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Total Synthesis of (+)-Conolidine by the Gold(I)-Catalyzed Cascade Cyclization of a Conjugated Enyne
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2016-06-20 00:00:00 , DOI: 10.1021/acs.joc.6b00720
Saori Naoe ₁ , Yusuke Yoshida ₁ , Shinya Oishi ₁ , Nobutaka Fujii ₁ , Hiroaki Ohno ₁

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A total synthesis of (+)-conolidine has been achieved via the gold(I)-catalyzed cascade cyclization of a conjugated enyne. Remarkably, this strategy allowed for the simultaneous formation of the indole ring and the ethylidene-substituted piperidine moiety of (+)-conolidine under homogeneous gold catalysis in an enantioselective manner (88–91% ee).

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