Antimicrobial drug, tinidazole has been synthesized by condensation of 2-methyl,5-nitro-imidazole and 2-ethyl-thio-ethanol over MoO₃/SiO₂ catalyst to obtain 1-(2-ethyl-thio-ethanol)-2-methyl-5-nitro-imidazole which is further oxidized using hydrogen peroxide using the same MoO₃/SiO₂ catalyst to obtain tinidazole. MoO₃/SiO₂ catalyst (20%), synthesized by sol–gel process showed the highest acid strength and was successfully demonstrated to catalyze both condensation and oxidation in the synthesis of tinidazole. Due to the bifunctional activity of the catalyst, the use of acetic acid for condensation step and tungstic acid or ammonium molybdate for oxidation step in the conventional synthesis of tinidazole could be eliminated, thus making it an environmentally benign process. The catalysts could be recycled five times without any appreciable loss in the conversion and selectivity showing the potential for the use of MoO₃/SiO₂ as bifunctional catalyst for the production of this industrially important compound.

中文翻译：

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MoO ₃ / SiO ₂双功能催化剂的缩合-氧化顺序合成替硝唑

抗菌药物替硝唑是通过在MoO ₃ / SiO ₂催化剂上将2-甲基，5-硝基咪唑和2-乙基硫代乙醇缩合而合成的，从而获得1-（2-乙基硫代乙醇）-2-使用相同的MoO ₃ / SiO ₂催化剂，使用过氧化氢进一步氧化甲基-5-硝基-咪唑，以获得替硝唑。MoO ₃ / SiO ₂通过溶胶-凝胶法合成的催化剂（20％）显示出最高的酸强度，并成功地证明了在合成替硝唑时催化缩合和氧化。由于该催化剂具有双功能活性，因此可以避免在替硝唑的常规合成中使用乙酸进行缩合步骤，而使用钨酸或钼酸铵进行氧化步骤，从而使其对环境无害。催化剂可以循环使用五次，而转化率和选择性没有任何明显的损失，显示出使用MoO ₃ / SiO ₂作为双官能催化剂生产这种工业上重要的化合物的潜力。