Total Synthesis of Thailanstatin A,Journal of the American Chemical Society

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Total Synthesis of Thailanstatin A
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2016-06-13 , DOI: 10.1021/jacs.6b04781
K. C. Nicolaou ₁ , Derek Rhoades , Manjunath Lamani , Manas R. Pattanayak , S. Mothish Kumar

Affiliation

The total synthesis of the spliceosome inhibitor thailanstatin A has been achieved in a longest linear sequence of nine steps from readily available starting materials. A key feature of the developed synthetic strategy is the implementation of a unique, biomimetic asymmetric intramolecular oxa-Michael reaction/hydrogenation sequence that allows diastereodivergent access to highly functionalized tetrahydropyrans, which can be used for the synthesis of designed analogues of this bioactive molecule.

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