In connection with our research of new antitumor compounds, previously undescribed approaches to the 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid 9 are reported here. Two related accesses from phenylethylamine or amphetamine were investigated and were found to be successful. A more robust synthesis, using Suzuki's cross-coupling between 2-chlorophenylboronic acid 15 and the previously unreported methyl-1-bromoisoquinoline-3-carboxylate 14 was also developed. This synthetic route provides the ground for a combinatorial approach to the core structure of new potential peripheral benzodiazepine receptor ligands.

中文翻译：

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1-（2-氯苯基）异喹啉-3-羧酸的合成方法

结合我们对新抗肿瘤化合物的研究，此处报道了先前未描述的1-（2-氯苯基）异喹啉-3-羧酸9的方法。来自的两个相关访问苯乙胺 或者 安非他命被调查并发现是成功的。还开发了一种更可靠的合成方法，它使用了2-氯苯基硼酸15与以前未报道的1-溴异喹啉-3-羧酸甲酯14之间的Suzuki交联反应。这种综合途径为新的潜在外设的核心结构的组合方法提供了基础苯二氮卓 受体 配体。