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Aerobic α-hydroxylation of β-keto esters and amides by co-catalysis of SmI3 and I2 under mild base-free conditions
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2016-05-30 19:08:50
Shun-Ming Yu, Kai Cui, Fei Lv, Zhen-Yu Yang, Zhu-Jun Yao
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2016-05-30 19:08:50
Shun-Ming Yu, Kai Cui, Fei Lv, Zhen-Yu Yang, Zhu-Jun Yao
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A clean base-free α-hydroxylation of β-keto esters and amides has been developed, in which air was used as the oxygen source and SmI3 and I2 were applied as the catalysts, affording the corresponding α-hydroxylated 1,3-dicarbonyl products in good to excellent yields under mild conditions. Mechanism discussion shows that both oxygen atoms of dioxygen are utilized and incorporated into the product through a unique free-radical process.
中文翻译:
在温和的无碱条件下,通过SmI3和I2的共催化,使β-酮酯和酰胺的好氧性α-羟基化
已经开发出清洁的无β-酮酯和酰胺的无碱α-羟基化反应,其中使用空气作为氧源,并使用SmI 3和I 2作为催化剂,得到相应的α-羟基化的1,3-在温和条件下,二羰基产品的收率好至极好。机理讨论表明,双氧的两个氧原子都被利用,并通过独特的自由基过程掺入产物中。
更新日期:2016-05-31
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
在温和的无碱条件下,通过SmI3和I2的共催化,使β-酮酯和酰胺的好氧性α-羟基化
已经开发出清洁的无β-酮酯和酰胺的无碱α-羟基化反应,其中使用空气作为氧源,并使用SmI 3和I 2作为催化剂,得到相应的α-羟基化的1,3-在温和条件下,二羰基产品的收率好至极好。机理讨论表明,双氧的两个氧原子都被利用,并通过独特的自由基过程掺入产物中。