A unique and efficient 2,2,2-trifluoroethanol-activated one-pot reaction of β-nitroenamines, secondary amines and aromatic aldehydes was developed under mild and convenient conditions. In the presence of 2,2,2-trifluoroethanol (TFEA), aromatic aldehydes were activated by hydrogen bonding with TFEA. The newly-developed reaction could afford the desired Mannich-like products in moderate to excellent yields with wide substrate scopes.

中文翻译：

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β-亚硝胺，仲胺和芳香醛的2,2,2-三氟乙醇活化一锅曼尼希样反应

在温和且方便的条件下，开发了独特且有效的2,2,2-三氟乙醇活化的一锅法反应的β-亚硝胺，仲胺和芳香醛。在2,2,2-三氟乙醇（TFEA）的存在下，芳香醛通过与TFEA的氢键键合而活化。新开发的反应可以以中等到极好的收率提供所需的类曼尼希样产物，并且具有广泛的底物范围。