Integrated Heterogeneous Metal/Enzymatic Multiple Relay Catalysis for Eco-Friendly and Asymmetric Synthesis,ACS Catalysis

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Integrated Heterogeneous Metal/Enzymatic Multiple Relay Catalysis for Eco-Friendly and Asymmetric Synthesis
ACS Catalysis ( IF 11.3 ) Pub Date : 2016-05-20 00:00:00 , DOI: 10.1021/acscatal.6b01031
Carlos Palo-Nieto ₁ , Samson Afewerki ₁ , Mattias Anderson ₂ , Cheuk-Wai Tai ₃ , Per Berglund ₂ , Armando Córdova _{1,

3}

Affiliation

Organic synthesis is in general performed using stepwise transformations where isolation and purification of key intermediates is often required prior to further reactions. Herein we disclose the concept of integrated heterogeneous metal/enzymatic multiple relay catalysis for eco-friendly and asymmetric synthesis of valuable molecules (e.g., amines and amides) in one-pot using a combination of heterogeneous metal and enzyme catalysts. Here reagents, catalysts, and different conditions can be introduced throughout the one-pot procedure involving multistep catalytic tandem operations. Several novel cocatalytic relay sequences (reductive amination/amidation, aerobic oxidation/reductive amination/amidation, reductive amination/kinetic resolution and reductive amination/dynamic kinetic resolution) were developed. They were next applied to the direct synthesis of various biologically and optically active amines or amides in one-pot from simple aldehydes, ketones, or alcohols, respectively.

中文翻译：

集成的多相金属/酶多中继催化，用于生态友好和不对称合成

通常使用逐步转化来进行有机合成，其中通常需要在进一步反应之前分离和纯化关键中间体。本文中，我们公开了使用非均相金属和酶催化剂的组合，在一个锅中以生态友好和不对称方式合成有价值分子（例如胺和酰胺）的非均相金属/酶多重中继集成催化的概念。在此，可以在涉及多步催化串联操作的一锅法中引入试剂，催化剂和不同条件。开发了几种新颖的共催化中继序列（还原胺化/酰胺化，有氧氧化/还原胺化/酰胺化，还原胺化/动力学拆分和还原胺化/动态动力学拆分）。

更新日期：2016-05-20

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