C.I. Acid Blue 78 is an important acid dye; its manufacture depends on 1-nitroanthraquinone and all procedures developed for the mononitration of anthraquinone give by-products such as dinitroanthraquinones. This paper presents a new method for the manufacture of C.I. Acid Blue 78 in high yield and good quality. HPLC was used to follow the formation of nitroanthraquinone from anthraquinone, which allowed the nitration of anthraquinone to be stopped at 35–45% conversion to 1-nitroanthraquinone, as the formation of by-products at this point was minimal. At the end of the formation of C.I. Acid Blue 78 from anthraquinone, residual, unreacted anthraquinone was reused for nitration after a single recrystallization stage from acetic acid.

中文翻译：

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一种方便高效的苯磺酸2-（（4-氨基-3-溴-9,10-二氢-9,10-二氧代-1-蒽基）氨基）-5-甲基单钠盐（CI的生产方法）酸性蓝78）直接来自蒽醌

CI酸性蓝78是重要的酸性染料。它的生产依赖于1-硝基蒽醌，开发的所有蒽醌单硝化程序都会产生副产物，例如二硝基蒽醌。本文提出了一种高产率，高品质的CI酸性蓝78的生产新方法。HPLC用于追踪由蒽醌形成的硝基蒽醌，这使蒽醌的硝化停止在35-45％转化为1-硝基蒽醌的过程中，因为此时副产物的生成极少。在由蒽醌形成CI酸性蓝78的最后，残留的未反应的蒽醌在从乙酸中重结晶一次后便重新用于硝化反应。