2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethanamine is the key intermediate of Silodosin, the α₁-adrenoceptor antagonist for the treatment of benign prostatic hyperplasia. In order to obtain this intermediate, we developed a novel synthetic route by utilizing 2-nitrochlorobenzene as the starting material via O-alkylation, reduction, diazotization, acidolysis, etherification, condensation and hydrazinolysis. The highlight of this method lies on its convenience and economy in accessing this intermediate.

中文翻译：

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2- [2-（2-（2,2,2-三氟乙氧基）苯氧基]乙胺的新颖合成途径

2- [2-（2,2,2-三氟乙氧基）苯氧基]乙胺为西洛多辛，所述α的关键中间体₁ -肾上腺素能受体拮抗剂用于治疗良性前列腺增生的治疗。为了获得该中间体，我们通过以2-硝基氯苯为原料，通过O-烷基化，还原，重氮化，酸解，醚化，缩合和肼解，开发了一种新颖的合成路线。该方法的亮点在于使用该中间体的便利性和经济性。