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The first facile total synthesis of natural (3R,4R,6S)-3,4-epoxybisabola-7(14),10-dien-2-one
Chinese Chemical Letters ( IF 9.4 ) Pub Date : 2009 , DOI: 10.1016/j.cclet.2009.03.010
Zhi Yong Tang , Chen Xi Zhang , Li Jing Fang , Yu Lin Li

3,4-Epoxybisabola-7(14),10-dien-2-one, a natural sesquiterpoind, was first synthesized from (−)-carvone through 7 steps, in an overall yield of 35.9%. The key step was the allylation and then a substrate-directable epoxidation was committed successfully.

中文翻译:

天然(3 R,4 R,6 S)-3,4-epoxybisabola-7(14),10-dien-2-one的第一个简便的全合成方法

首先,通过(-)-香芹酮经7个步骤合成了天然的倍半萜烯3,4-Epoxybisabola-7(14),10-dien-2-one,总产率为35.9%。关键步骤是烯丙基化,然后成功进行了底物导向的环氧化。
更新日期:2017-01-31
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