Urochrome Pigment in Uric Acid Crystals,Chemistry of Materials

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Urochrome Pigment in Uric Acid Crystals
Chemistry of Materials ( IF 7.2 ) Pub Date : 2016-05-16 00:00:00 , DOI: 10.1021/acs.chemmater.6b00977
Victoria M. Hall ₁ , Kristin A. Cox ₁ , Ryan E. Sours ₁ , Jennifer A. Swift ₁

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Renal stones are heterogeneous composites of numerous microscopic crystals (e.g., calcium oxalate, calcium phosphate, uric acid, etc.) and 2–3 wt % amorphous organic “matrix”. Uric acid kidney stones are often red–orange–brown in color, though uric acid crystals are colorless. The stone color originates from a variety of components in the matrix, some of which are a broad range of urinary pigments or urochrome. Herein, we report the first definitive structure of one of these pigments, urorosein, and its ability to form intracrystalline inclusions in single crystals of both anhydrous uric acid and uric acid dihydrate. The preferred orientation of the included urorosein molecules in the uric acid crystals was determined through polarized light microspectroscopy. On the basis of these results, it seems likely that other urochrome pigments can locate in both intercrystalline and intracrystalline spaces in urinary precipitates. This expands the conventional picture of where “matrix” resides in these composite materials.

中文翻译：

尿酸晶体中的铀铬颜料

肾结石是许多微观晶体（例如草酸钙，磷酸钙，尿酸等）和2-3 wt％的非晶态有机“基质”的异质复合物。尿酸肾结石的颜色通常为红橙色棕，尽管尿酸晶体为无色。石头的颜色源自基质中的各种成分，其中一些成分是多种尿色素或尿色素。在本文中，我们报告了其中一种颜料尿素的第一个确定性结构，及其在无水尿酸和尿酸二水合物的单晶中形成晶体内夹杂物的能力。通过偏振光光谱法确定尿酸晶体中所包含的尿苷酶分子的优选取向。根据这些结果，似乎其他的尿色素可以同时存在于尿液沉淀物的晶间和晶内空间中。这扩大了传统的图像，即这些复合材料中“基质”的位置。

更新日期：2016-05-16

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