Double‐Network Hydrogels Strongly Bondable to Bones by Spontaneous Osteogenesis Penetration,Advanced Materials

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Double‐Network Hydrogels Strongly Bondable to Bones by Spontaneous Osteogenesis Penetration
Advanced Materials ( IF 27.4 ) Pub Date : 2016-05-17 , DOI: 10.1002/adma.201601030
Takayuki Nonoyama _{1,

2} , Susumu Wada ₃ , Ryuji Kiyama ₄ , Nobuto Kitamura ₃ , Md.Tariful Islam Mredha ₄ , Xi Zhang ₅ , Takayuki Kurokawa _{1,

2} , Tasuku Nakajima _{1,

2} , Yasuaki Takagi ₅ , Kazunori Yasuda ₃ , Jian Ping Gong _{1,

2}

Affiliation

On implanting hydroxyapatite‐mineralized tough hydrogel into osteochondral defects of rabbits, osteogenesis spontaneously penetrates into the gel matrix owing to the semi‐permeablility of the hydrogel. The gradient layer (around 40 μm thick) contributes quite strong bonding of the gel to bone. This is the first success in realizing the robust osteointegration of tough hydrogels, and the method is simple and feasible for practical use.