A facile synthesis of suvorexant, an orexin receptor antagonist, is described. The key intermediate 6 was prepared from R-3-aminobutyric acid through protection, condensation, deprotection, cyclization, and hydrogenation steps. The title product was obtained with a total yield of 31% (>99% ee) after eight linear steps using commercially available raw materials.

中文翻译：

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通过手性二氮杂庚烷中间体轻松合成suvorexant（一种orexin受体拮抗剂）

描述了一种容易合成的食欲素受体拮抗剂suvorexant。关键中间体6由R -3-氨基丁酸通过保护，缩合，脱保护，环化和氢化步骤制备。经过八个线性步骤，使用商购可得的原料，获得标题产物，总收率为31％（ee > 99％ee）。