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Electro-catalyzed multicomponent transformation of 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one to 1,4-dihydropyrano[2,3-c]pyrazole derivatives in green medium
Chinese Chemical Letters ( IF 9.4 ) Pub Date : 2015 , DOI: 10.1016/j.cclet.2015.04.016 Zahra Vafajoo , Nourallah Hazeri , Malek Taher Maghsoodlou , Hojat Veisi
Chinese Chemical Letters ( IF 9.4 ) Pub Date : 2015 , DOI: 10.1016/j.cclet.2015.04.016 Zahra Vafajoo , Nourallah Hazeri , Malek Taher Maghsoodlou , Hojat Veisi
An efficient and convenient synthesis of 1,4-dihydropyrano[2,3-c]pyrazole derivatives is described, using the electrogenerated anion of ethanol as the base in the presence of sodium bromide as an supporting electrolyte in a one-pot, three component condensation of malononitrile, aromatic aldehydes and 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one. The reaction is carried out in an undivided cell containing an iron electrode as the cathode and a graphite electrode as the anode, at a constant current at room temperature.
中文翻译:
绿色介质中3-甲基-1-苯基-1 H-吡唑-5(4 H)-one的电催化多组分转化为1,4-二氢吡喃并[2,3-c]吡唑衍生物
描述了一种有效且方便的合成1,4-二氢吡喃并[2,3-c]吡唑衍生物的方法,该方法使用电生成的乙醇阴离子作为碱,在溴化钠作为辅助电解质的情况下,在一锅三组分中使用丙二腈,芳族醛与3-甲基-1-苯基-1 H-吡唑-5(4 H)-一的缩合反应。反应在室温下以恒定电流在包含铁电极作为阴极和石墨电极作为阳极的不分隔电池中进行。
更新日期:2017-01-31
中文翻译:
绿色介质中3-甲基-1-苯基-1 H-吡唑-5(4 H)-one的电催化多组分转化为1,4-二氢吡喃并[2,3-c]吡唑衍生物
描述了一种有效且方便的合成1,4-二氢吡喃并[2,3-c]吡唑衍生物的方法,该方法使用电生成的乙醇阴离子作为碱,在溴化钠作为辅助电解质的情况下,在一锅三组分中使用丙二腈,芳族醛与3-甲基-1-苯基-1 H-吡唑-5(4 H)-一的缩合反应。反应在室温下以恒定电流在包含铁电极作为阴极和石墨电极作为阳极的不分隔电池中进行。