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Water-Mediated Collagen and Mineral Nanoparticle Interactions Guide Functional Deformation of Human Tooth Dentin
Chemistry of Materials ( IF 7.2 ) Pub Date : 2016-05-06 00:00:00 , DOI: 10.1021/acs.chemmater.6b00811 Jean-Baptiste Forien 1 , Ivo Zizak 2 , Claudia Fleck 3 , Ansgar Petersen 1, 4 , Peter Fratzl 5 , Emil Zolotoyabko 6 , Paul Zaslansky 1
Chemistry of Materials ( IF 7.2 ) Pub Date : 2016-05-06 00:00:00 , DOI: 10.1021/acs.chemmater.6b00811 Jean-Baptiste Forien 1 , Ivo Zizak 2 , Claudia Fleck 3 , Ansgar Petersen 1, 4 , Peter Fratzl 5 , Emil Zolotoyabko 6 , Paul Zaslansky 1
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Dentin in teeth is a bone-like nanocomposite built of carbonated hydroxyapatite (cHAP) mineral particles, protein, and water. It does not remodel nor heal and is excellently adapted for decades of mechanical function, due to the interplay between its constituents. Using samples of human origin, we combine heat treatments with synchrotron X-ray diffraction, second-harmonic generation microscopy, Raman spectroscopy, and phase contrast-enhanced nanotomography to study the water-assisted functional coupling of the biocomposite components. Across roots we find a gradual reduction in the c-lattice parameter of the cHAP nanocrystals, from 6.894 Å externally down to 6.885 Å on the inside. Thus, the tissue formed at later stages of tooth development around the pulp contains crystals with smaller unit cells. In all regions, a compressive strain of ∼0.3% is observed upon drying by mild heating (125 °C). Dehydration also results in a substantial increase in the averaged microstrain fluctuations in the mineral nanoparticles. The mineral crystallite platelet lengths fall off from ∼36 nm externally to ∼26 nm closer to the pulp. Our results suggest that both morphology and tight mineral–collagen coupling allow mineral nanoparticles in dentin to sustain rather large stresses of 300 MPa, far exceeding mastication loads.
中文翻译：
水介导的胶原蛋白和矿物质纳米粒子相互作用指导人类牙齿牙本质的功能变形
牙齿中的牙本质是一种由碳酸盐羟基磷灰石（cHAP）矿物颗粒，蛋白质和水构成的骨状纳米复合材料。它不会重塑或愈合，并且由于其成分之间的相互作用而非常适合数十年的机械功能。使用人类来源的样品，我们将热处理与同步加速器X射线衍射，二次谐波产生显微镜，拉曼光谱和相衬增强纳米断层扫描相结合，以研究生物复合材料的水辅助功能耦合。从各个根源来看，我们发现C逐渐降低cHAP纳米晶体的晶格参数，从外部的6.894Å到内部的6.885Å。因此，在牙髓周围牙齿发育的后期阶段形成的组织包含具有较小晶胞的晶体。在所有区域，通过适度加热（125°C）干燥后，观察到的压缩应变约为0.3％。脱水还导致矿物纳米颗粒中平均微应变波动显着增加。矿物微晶片的长度从外部〜36 nm下降到更接近纸浆的〜26 nm。我们的结果表明，形态和紧密的矿物-胶原耦合都使牙本质中的矿物纳米颗粒承受300 MPa的相当大的应力，远远超过咀嚼负荷。
更新日期：2016-05-06
中文翻译：
水介导的胶原蛋白和矿物质纳米粒子相互作用指导人类牙齿牙本质的功能变形
牙齿中的牙本质是一种由碳酸盐羟基磷灰石（cHAP）矿物颗粒，蛋白质和水构成的骨状纳米复合材料。它不会重塑或愈合，并且由于其成分之间的相互作用而非常适合数十年的机械功能。使用人类来源的样品，我们将热处理与同步加速器X射线衍射，二次谐波产生显微镜，拉曼光谱和相衬增强纳米断层扫描相结合，以研究生物复合材料的水辅助功能耦合。从各个根源来看，我们发现C逐渐降低cHAP纳米晶体的晶格参数，从外部的6.894Å到内部的6.885Å。因此，在牙髓周围牙齿发育的后期阶段形成的组织包含具有较小晶胞的晶体。在所有区域，通过适度加热（125°C）干燥后，观察到的压缩应变约为0.3％。脱水还导致矿物纳米颗粒中平均微应变波动显着增加。矿物微晶片的长度从外部〜36 nm下降到更接近纸浆的〜26 nm。我们的结果表明，形态和紧密的矿物-胶原耦合都使牙本质中的矿物纳米颗粒承受300 MPa的相当大的应力，远远超过咀嚼负荷。
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