Reductive Umpolung of Carbonyl Derivatives with Visible-Light Photoredox Catalysis: Direct Access to Vicinal Diamines and Amino Alcohols via α-Amino Radicals and Ketyl Radicals.,Angewandte Chemie International Edition

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Reductive Umpolung of Carbonyl Derivatives with Visible-Light Photoredox Catalysis: Direct Access to Vicinal Diamines and Amino Alcohols via α-Amino Radicals and Ketyl Radicals.
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2016-05-02 , DOI: 10.1002/anie.201511235
Eleonora Fava ₁ , Anthony Millet ₁ , Masaki Nakajima ₁ , Sebastian Loescher ₁ , Magnus Rueping _{1,

2}

Affiliation

Visible-light-mediated photoredox-catalyzed aldimine-aniline and aldehyde-aniline couplings have been realized. The reductive single electron transfer (SET) umpolung of various carbonyl derivatives enabled the generation of intermediary ketyl and α-amino radical anions, which were utilized for the synthesis of unsymmetrically substituted 1,2-diamines and amino alcohols.

中文翻译：

用可见光光氧化还原催化还原羰基衍生物：通过α-氨基自由基和酮基自由基直接获得邻二胺和氨基醇。

已经实现了可见光介导的光氧化还原催化的醛亚胺-苯胺和醛-苯胺偶联。各种羰基衍生物的还原性单电子转移 (SET) umpolung 能够产生中间的酮基和 α-氨基自由基阴离子，这些阴离子可用于合成不对称取代的 1,2-二胺和氨基醇。

更新日期：2016-05-02

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