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Self-Assembled Core–Satellite Gold Nanoparticle Networks for Ultrasensitive Detection of Chiral Molecules by Recognition Tunneling Current
ACS Nano ( IF 15.8 ) Pub Date : 2016-04-29 00:00:00 , DOI: 10.1021/acsnano.6b00216 Yuanchao Zhang 1, 2 , Jingquan Liu 3 , Da Li 3 , Xing Dai 4 , Fuhua Yan 5 , Xavier A. Conlan 2 , Ruhong Zhou 4, 6 , Colin J. Barrow 2 , Jin He 7 , Xin Wang 1 , Wenrong Yang 2
ACS Nano ( IF 15.8 ) Pub Date : 2016-04-29 00:00:00 , DOI: 10.1021/acsnano.6b00216 Yuanchao Zhang 1, 2 , Jingquan Liu 3 , Da Li 3 , Xing Dai 4 , Fuhua Yan 5 , Xavier A. Conlan 2 , Ruhong Zhou 4, 6 , Colin J. Barrow 2 , Jin He 7 , Xin Wang 1 , Wenrong Yang 2
Affiliation
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Chirality sensing is a very challenging task. Here, we report a method for ultrasensitive detection of chiral molecule l/d-carnitine based on changes in the recognition tunneling current across self-assembled core–satellite gold nanoparticle (GNP) networks. The recognition tunneling technique has been demonstrated to work at the single molecule level where the binding between the reader molecules and the analytes in a nanojunction. This process was observed to generate a unique and sensitive change in tunneling current, which can be used to identify the analytes of interest. The molecular recognition mechanism between amino acid l-cysteine and l/d-carnitine has been studied with the aid of SERS. The different binding strength between homo- or heterochiral pairs can be effectively probed by the copper ion replacement fracture. The device resistance was measured before and after the sequential exposures to l/d-carnitine and copper ions. The normalized resistance change was found to be extremely sensitive to the chirality of carnitine molecule. The results suggested that a GNP networks device optimized for recognition tunneling was successfully built and that such a device can be used for ultrasensitive detection of chiral molecules.
中文翻译：
自组装核-卫星金纳米粒子网络用于通过识别隧穿电流超灵敏地检测手性分子。
手性感测是一项非常具有挑战性的任务。在这里，我们报告了一种基于跨自组装核-卫星金纳米粒子（GNP）网络的识别隧穿电流变化的手性分子l / d-肉碱超灵敏检测方法。事实证明，识别隧道技术可在单分子水平上发挥作用，在该水平上，阅读器分子与纳米结中的分析物之间的结合。观察到此过程会在隧道电流中产生独特而敏感的变化，可用于识别目标分析物。氨基酸l-半胱氨酸与l / d的分子识别机理-肉碱已在SERS的帮助下进行了研究。铜离子置换断裂可以有效地探测同手性或异手性对之间的不同结合强度。在依次暴露于l / d-肉碱和铜离子之前和之后测量器件电阻。发现归一化的电阻变化对肉碱分子的手性极为敏感。结果表明，成功构建了针对识别隧道优化的GNP网络设备，该设备可用于手性分子的超灵敏检测。
更新日期：2016-04-29
中文翻译：
自组装核-卫星金纳米粒子网络用于通过识别隧穿电流超灵敏地检测手性分子。
手性感测是一项非常具有挑战性的任务。在这里，我们报告了一种基于跨自组装核-卫星金纳米粒子（GNP）网络的识别隧穿电流变化的手性分子l / d-肉碱超灵敏检测方法。事实证明，识别隧道技术可在单分子水平上发挥作用，在该水平上，阅读器分子与纳米结中的分析物之间的结合。观察到此过程会在隧道电流中产生独特而敏感的变化，可用于识别目标分析物。氨基酸l-半胱氨酸与l / d的分子识别机理-肉碱已在SERS的帮助下进行了研究。铜离子置换断裂可以有效地探测同手性或异手性对之间的不同结合强度。在依次暴露于l / d-肉碱和铜离子之前和之后测量器件电阻。发现归一化的电阻变化对肉碱分子的手性极为敏感。结果表明，成功构建了针对识别隧道优化的GNP网络设备，该设备可用于手性分子的超灵敏检测。
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