New amination strategies based on nitrogen-centered radical chemistry,Chemical Society Reviews

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New amination strategies based on nitrogen-centered radical chemistry
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2016-04-27 00:00:00 , DOI: 10.1039/c5cs00852b
Tao Xiong _{1,

2,

3,

4} , Qian Zhang _{1,

2,

3,

4}

Affiliation

The interesting and diverse biological activities of nitrogen-containing compounds make the construction of the C–N bond of great importance. Despite the tremendous advances that have been made in this research field, C–N bond formation based on nitrogen-centered radicals remains a significant challenge due to the harsh conditions required for the generation of nitrogen-centered radicals and their propensity for hydrogen abstraction or engaging in other degradation pathways. In the past several years, novel methodologies for C–N bond constructions based on nitrogen centered-radical intermediates, coordinated with metal or generated in the presence of visible-light and a photocatalyst, have attracted considerable attention. This tutorial review will summarize the significant progress of these efficient and mild radical amination reactions, with an emphasis on approaches for the generation of nitrogen-centered radicals and their reaction patterns, related mechanisms and synthetic applications, as well as unmet challenges in this emerging and promising field.

中文翻译：

基于氮中心自由基化学的新胺化策略

含氮化合物有趣而多样的生物活性使得C–N键的构建非常重要。尽管在该研究领域已取得了巨大的进步，但由于生成以氮为中心的自由基所需要的苛刻条件以及它们提取氢或参与氢的倾向，基于氮中心的自由基形成C–N键仍然是一个巨大的挑战。在其他降解途径中。在过去的几年中，基于氮中心自由基中间体，与金属配位或在可见光和光催化剂存在下生成的CN键结构的新方法吸引了相当多的关注。本教程的回顾将总结这些有效和温和的自由基胺化反应的重大进展，

更新日期：2016-04-27

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