Efficient synthesis of quinazoline-2,4(1H,3H)-diones from CO2 catalyzed by N-heterocyclic carbene at atmospheric pressure,RSC Advances

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Efficient synthesis of quinazoline-2,4(1H,3H)-diones from CO2 catalyzed by N-heterocyclic carbene at atmospheric pressure
RSC Advances ( IF 3.9 ) Pub Date : 2014-12-11 00:00:00 , DOI: 10.1039/c4ra13752c
Yunqing Xiao _{1,

2,

3,

4} , Xianqiang Kong _{1,

2,

3,

4} , Zhicheng Xu _{1,

2,

3,

4} , Changsheng Cao _{1,

2,

3,

4} , Guangsheng Pang _{4,

5,

6,

7,

8} , Yanhui Shi _{1,

2,

3,

4}

Affiliation

Under atmospheric pressure, quinazoline-2,4(1H,3H)-diones were obtained from the reaction of 2-aminobenzonitriles with carbon dioxide (0.1 MPa) with a catalytic amount of N-heterocyclic carbene in DMSO. It was found that various electron-donating and electron-withdrawing groups such as –OMe, –F, –Cl, –Br, –CH₃, –CF₃ and –CN were well tolerated to give the products in almost quantitative yields.

中文翻译：

N-杂环卡宾在大气压下由CO ₂ 高效合成喹唑啉-2,4（1 H，3 H）-二酮

在大气压下，由2-氨基苄腈与二氧化碳（0.1 MPa）与催化量的N-杂环卡宾在DMSO中的反应制得喹唑啉-2,4（1 H，3 H）-二酮。发现各种给电子基团和吸电子基团，例如–OMe，–F，–Cl，–Br，–CH ₃，–CF ₃和–CN都具有良好的耐受性，从而以几乎定量的产率获得了产物。

更新日期：2014-12-11

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