A novel naphthalimide-based fluorescent probe was designed and synthesized for thiol recognition with high sensitivity and excellent selectivity. The probe can detect thiol quantitatively in a concentration range of 0–6.0 μM and the detection limit could be as low as 1.6 nM. The fluorescence enhancement of this probe upon addition of Cys on test paper and the application of the probe for selective detection of intracellular Hcy, GSH and Cys have been successfully demonstrated.

中文翻译：

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对水溶液，试纸和活细胞中的Hcy，GSH和Cys进行纳摩尔检测†

设计并合成了一种新颖的基于萘二甲酰亚胺的荧光探针，用于硫醇识别，具有高灵敏度和出色的选择性。该探针可以在0–6.0μM的浓度范围内定量检测硫醇，并且检测限可能低至1.6 nM。已经成功地证明了在探针上添加半胱氨酸后该探针的荧光增强以及该探针在选择性检测细胞内半胱氨酸，谷胱甘肽和半胱氨酸中的应用。