A variety of mono- and diethynyl substituted fluorinated benzene derivatives was prepared by Sonogashira cross coupling reactions of 1,2-dibromo-3,5-difluorobenzene. The reactions proceed with very good site-selectivity in favor of position 1, due to electronic and steric reasons.

中文翻译：

---

1,2-二溴-3,5-二氟苯的定点Sonogashira反应

通过1,2-二溴-3,5-二氟苯的Sonogashira交叉偶联反应制备了各种单和二乙炔基取代的氟化苯衍生物。由于电子和空间原因，反应以非常好的位点选择性进行，有利于位置1。