An efficient continuous flow iron-catalyzed Kumada cross-coupling was developed for the coupling of 2-chloropyrazine and various aryl Grignard reagents in presence of low catalyst loadings (0.5 mol-%). Compared to batch mode, the continuous flow approach overcomes the exothermicity which enabled longer catalyst lifetime, facilitated scale-up and significantly improved the yield. To the best of our knowledge, this is the first example of flow iron-catalyzed Kumada cross-coupling reactions which addresses scale dependence issues which often plague Kumada reactions carried out in the traditional batch mode.

中文翻译：

---

在低催化剂负载下利用流动技术进行高效的铁催化 Kumada 交叉偶联反应

开发了一种高效的连续流动铁催化 Kumada 交叉偶联，用于在低催化剂负载（0.5 mol%）存在下偶联 2-氯吡嗪和各种芳基格氏试剂。与间歇模式相比，连续流动方法克服了放热问题，从而延长了催化剂寿命，促进了放大并显着提高了产率。据我们所知，这是流动铁催化的熊田交叉偶联反应的第一个例子，它解决了规模依赖性问题，这些问题经常困扰以传统间歇模式进行的熊田反应。