Metal–Organic Framework Capillary Microreactor for Application in Click Chemistry,ChemCatChem

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Metal–Organic Framework Capillary Microreactor for Application in Click Chemistry
ChemCatChem ( IF 3.8 ) Pub Date : 2016-04-18 , DOI: 10.1002/cctc.201600016
Lara A. Truter ₁ , Jana Juan-Alcañiz ₂ , Freek Kapteijn ₂ , Tjeerd A. Nijhuis ₁ , Jorge Gascon ₂ , Jaap C. Schouten ₁

Affiliation

A Cu/PMA–MIL‐101(Cr) metal–organic‐framework‐coated microreactor has been applied in the 1,3‐dipolar cycloaddition of benzyl azide and phenylactetylene (click chemistry). The Cu/PMA–MIL‐101(Cr) catalyst was incorporated by using a washcoating method. The use of tetraethylorthosilicate (TEOS) and a copolymer pluronic F127 as binders resulted in a stable and uniform coating of 6 μm. The application of the Cu/PMA–MIL‐101(Cr) capillary microreactor in the click‐chemistry reaction resulted in a similar intrinsic activity as in the batch reactor, and a continuous production for more than 150 h time‐on‐stream could be achieved. The presence of water in the reagent feed led to reversible catalyst deactivation and was necessary to be removed to obtain a stable catalyst operation.

中文翻译：

金属有机骨架毛细管微反应器在点击化学中的应用

Cu / PMA-MIL-101（Cr）金属-有机骨架涂层微反应器已用于叠氮化苄和苯乙炔的1,3-偶极环加成反应（点击化学反应）。铜/ PMA–MIL-101（Cr）催化剂是通过修补基面涂层法掺入的。使用原硅酸四乙酯（TEOS）和共聚物pluronic F127作为粘合剂可产生稳定且均匀的6μm涂层。在点击化学反应中使用Cu / PMA–MIL-101（Cr）毛细管微反应器具有与分批反应器类似的固有活性，可以连续生产150小时以上实现。试剂进料中水的存在导致可逆的催化剂失活，必须除去水以获得稳定的催化剂操作。

更新日期：2016-04-18

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