转录后修饰调节rRNA结构和配体相互作用。,Accounts of Chemical Research

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转录后修饰调节rRNA结构和配体相互作用。
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2016-04-11 00:00:00 , DOI: 10.1021/acs.accounts.6b00014
Jun Jiang ₁ , Hyosuk Seo ₁ , Christine S. Chow ₁

Affiliation

转录后修饰在调节RNA种类的功能中起重要作用。RNA中修饰的存在可能直接改变其与结合配偶体的相互作用，或引起间接影响配体识别的结构变化。鉴于在非编码和与人类疾病相关的mRNA中鉴定出的修饰迅速增加，以及对各种生理过程中涉及的修饰的动态控制，必须了解通过这些修饰进行的RNA结构调节。在RNA物种中，rRNA提供了许多位于不同序列和结构背景下的修饰类型实例。此外，修饰的rRNA基序还参与各种配体相互作用，包括与RNA，蛋白质和小分子的相互作用。实际上，几类抗生素通过与rRNA的功能重要且高度修饰的区域结合来发挥其对蛋白质合成的作用。这些RNA区域通常在序列，二级结构，三级相互作用和修饰，理想药物靶向位点的商标上显示出保守性。此外，配体与这些区域的相互作用通常有利于RNA的某些修饰诱导的构象状态。

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Post-transcriptional Modifications Modulate rRNA Structure and Ligand Interactions

Post-transcriptional modifications play important roles in modulating the functions of RNA species. The presence of modifications in RNA may directly alter its interactions with binding partners or cause structural changes that indirectly affect ligand recognition. Given the rapidly growing list of modifications identified in noncoding and mRNAs associated with human disease, as well as the dynamic control over modifications involved in various physiological processes, it is imperative to understand RNA structural modulation by these modifications. Among the RNA species, rRNAs provide numerous examples of modification types located in differing sequence and structural contexts. In addition, the modified rRNA motifs participate in a wide variety of ligand interactions, including those with RNA, protein, and small molecules. In fact, several classes of antibiotics exert their effects on protein synthesis by binding to functionally important and highly modified regions of the rRNAs. These RNA regions often display conservation in sequence, secondary structure, tertiary interactions, and modifications, trademarks of ideal drug-targeting sites. Furthermore, ligand interactions with such regions often favor certain modification-induced conformational states of the RNA.

更新日期：2016-04-11

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