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Benzothiazole Sulfinate: a Water-Soluble and Slow-Releasing Sulfur Dioxide Donor
ACS Chemical Biology ( IF 3.5 ) Pub Date : 2016-04-07 00:00:00 , DOI: 10.1021/acschembio.6b00106 Jacob J. Day 1 , Zhenhua Yang 2 , Wei Chen 1 , Armando Pacheco 1 , Ming Xian 1, 2
ACS Chemical Biology ( IF 3.5 ) Pub Date : 2016-04-07 00:00:00 , DOI: 10.1021/acschembio.6b00106 Jacob J. Day 1 , Zhenhua Yang 2 , Wei Chen 1 , Armando Pacheco 1 , Ming Xian 1, 2
Affiliation
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Sulfur dioxide (SO2) has long been considered a toxic environmental pollutant and byproduct of industrial processing. Recently it has become evident that SO2 may also have regulatory functions in mammalian pulmonary systems. However, the study of these effects has proven to be challenging due to the difficulty in administering SO2 in a reliable manner. In this work, we report the discovery of a new pH-dependent and water-soluble SO2 donor, benzothiazole sulfinate (BTS). We have found BTS to have slow and sustained SO2 release at physiological pH. Additionally, we have explored its vasorelaxation properties as compared to the authentic SO2 gas solutions. The slow release of BTS should make it a useful tool for the study of endogenously generated SO2.
中文翻译：
苯并噻唑亚磺酸盐：水溶性和缓慢释放的二氧化硫供体
二氧化硫（SO 2）长期以来一直被认为是有毒的环境污染物和工业加工的副产品。最近，已经明显的是，SO 2在哺乳动物的肺系统中也可能具有调节功能。然而，由于难以以可靠的方式施用SO 2，对这些作用的研究已证明是具有挑战性的。在这项工作中，我们报告发现了一种新的pH依赖性和水溶性SO 2供体苯并噻唑亚磺酸盐（BTS）。我们发现BTS在生理pH值下具有缓慢而持续的SO 2释放。此外，我们还研究了其与纯正SO 2相比的血管舒张特性气体解决方案。BTS的缓慢释放应使其成为研究内源性SO 2的有用工具。
更新日期：2016-04-07
中文翻译：
苯并噻唑亚磺酸盐：水溶性和缓慢释放的二氧化硫供体
二氧化硫（SO 2）长期以来一直被认为是有毒的环境污染物和工业加工的副产品。最近，已经明显的是，SO 2在哺乳动物的肺系统中也可能具有调节功能。然而，由于难以以可靠的方式施用SO 2，对这些作用的研究已证明是具有挑战性的。在这项工作中，我们报告发现了一种新的pH依赖性和水溶性SO 2供体苯并噻唑亚磺酸盐（BTS）。我们发现BTS在生理pH值下具有缓慢而持续的SO 2释放。此外，我们还研究了其与纯正SO 2相比的血管舒张特性气体解决方案。BTS的缓慢释放应使其成为研究内源性SO 2的有用工具。
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