【CSC博士招生】Queen Mary University of London 伦敦玛丽女王大学生物技术系招收化学生物学方向现招募2025年9月入学的CSC博士研究生 

1. 申请截止日期: 29 January 2025

2. 语言要求：IELTS总分6.5+，小分各项6.0+ （可以先面试再考雅思！）

导师：Dr Elena De Vita；合作导师：Dr Ben Stieglitz

邮箱：e.devita@qmul.ac.uk

课题组网页：https://edv-lab.com/ 

伦敦玛丽女王大学 (Queen Mary University of London)历史悠久，建于1885年，，是英国著名的公立研究型大学之一，以英国玛丽王后命名。伦敦玛丽女王大学是伦敦大学联合体中规模最大的学院之一，同时也是伦敦大学联盟中唯一的校园式大学，与伦敦大学的另外三个学院：UCL, Imperial College, King’s 并列为伦敦大学联盟的四大核心学院。也是英国罗素大学集团成员之一、科学与工程南联盟成员。2025年QS世界大学排名第120位；2025年THE世界大学排名位于第141位。

Protein regulation by post-translational modifications (PTMs) is essential for cellular homeostasis. For example, protein phosphorylation, the most prevalent PTM, dynamically directs the function of proteins, with >130,000 phosphosites identified in human cells.1 Modulating proteins by inducing functional PTMs is thus highly desirable for therapeutic purposes but remains challenging with conventional drug discovery approaches.

Recently, novel pharmacological modalities that work by inducing protein proximity with small molecules have emerged.2,3 This mechanism of action was first conceptualised in the design of PROTACs (PROteolysis TArgeting Chimeras), which cause ubiquitination of target proteins by recruiting them to an E3 ligase using bispecific ligands. PROTACs induce polyubiquitination, a tag endogenously used to redirect proteins to degradation via the proteasome system, hence PROTACs have proven effective in inducing protein degradation on demand.

This project will look at integrating highly interdisciplinary structure-based and chemical biology approaches to study and develop novel ligands for induced proximity modalities, such as PHOSphorylation Targeting Chimers (PHOSTACs).4 In particular, you will explore covalent approaches to tackle challenging protein targets.5 Using cellular and in vitro model systems you will study the use of covalency within induced proximity modalities focusing on pharmacodynamic effects. This work will provide a thorough understanding of the advantages and disadvantages of combining these drug discovery modalities to modulate protein PTMs.

This PhD project is at the cutting edge of sustainable materials research, with the potential to transform key industries by providing versatile, environmentally conscious composite solutions.

We are looking for candidates to have or expecting to receive a first or upper-second class honours degree and a Master’s degree in an area relevant to the project such as Chemical Biology, Drug Discovery, Biochemistry or Structural Biology.

Knowledge of protein purification and biochemistry, organic synthesis, and molecular and cell biology techniques would be highly advantageous but are not required.

You must meet the IELTS requirements for your course and upload evidence before CSC’s application deadline, ideally by 1st March 2025. You are therefore strongly advised to sit an approved English Language test as soon as possible, where your IELTS test must still be valid when you enrol for the programme.

更多详细情况请咨询邮箱：e.devita@qmul.ac.uk