Postdoc/Student on Decoding Brain Functions by Epigenome Editing The laboratory of Dr. Shawn Liu at Columbia University in New York City is seeking talented postdoc/student to study the epigenome in brain functions and disorders using newly developed cutting-edge technology. Three major research directions in our lab are 1) CRISPR-based epigenome editing tool development; 2) Epigenetic basis for learning and memory; and 3) To tackle human diseases by editing the epigenome. We are looking for highly motivated individuals with training in biology, chemistry, biophysics, or medicine. Experience in NGS analysis, molecular neuroscience, or CRISPR is preferred. We offer highly competitive salaries and benefits. The starting salary will be $65,000 per year. A generous benefits package that includes medical, dental, and vision coverage, as well as retirement savings and life insurance plans will be provided. Please check out our lab members and ongoing research projects at lab website (https://epibrain.info). Applicants should send your inquiry to Shawn Liu (SL4738@cumc.columbia.edu) along with your CV and names of references. Selected Publications:1. Qian, J., Guan, X., Xie, B., Xu, C., Niu, J., Tang, X., Li, C.H., Colecraft, H.M., Jaenisch, R. Liu, X.S. (2023). Multiplex Epigenome Editing of MECP2 to Rescue Rett Syndrome Neurons. Science Translational Medicine. 15(679):eadd4666. (Highlighted by Nature Reviews Neurology)2. Shpokayte, M., McKissick, O., Guan, X., Yuan, B., Rahsepar, B., Fernandez, F., Ruesch, E., Grella, S.L., White, J.A., Liu, X.S.*, Ramirez, S.* (2022). Hippocampal cells multiplex positive and negative engrams. Nature Communication Biology. 5(1):1009. (*corresponding author)3. Li, C.H., Coffey, E.L., Dall’Agnese, A., Hannett, N.M., Tang, X., Henninger, J.E., Platt, J.M., Oksuz, O., Zamudio, A.V., Afeyan, L.K., Schuijers, J., Liu, X.S., Markoulaki, S., Lungjangwa, T., LeRoy, G., Svoboda, D.S., Wogram, E., Lee, T.I., Jaenisch, R., Young, R.A. (2020). MeCP2 links heterochromatin condensates and neurodevelopmental disease. Nature. 586, 440–444.4. Liu, X.S., Wu, H., Krzisch, M., Wu, X., Graef, J., Muffat, J., Hnisz, D., Li, C.H., Yuan, B., Vershkov, D., Cacace. A., Young, R.A., and Jaenisch, R. (2018). Rescue of Fragile X syndrome by DNA methylation editing of the FMR1. Cell. 173, 1-14. (Highlighted by Nature Reviews Neuroscience and Nature Reviews Drug Discovery)5. Liu, X.S., Wu, H., Ji, X., Stelzer, Y., Wu, X., Czauderna, S., Shu, J., Dadon, D., Young, R.A., and Jaenisch, R. (2016). Editing DNA methylation in the mammalian genome. Cell. 167, 233-247. (Highlighted by Nature)
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