RSC主编推荐：纳米领域精彩文章快览（免费阅读原文）

英国皇家化学会（RSC）是一个超过175年历史的面向全球化学家的非营利会员制机构，旗下拥有44种期刊，其中很多在化学领域有很高影响力。为了进一步帮助广大读者追踪科技前沿热点，X-MOL团队与英国皇家化学会合作，推出英国皇家化学会期刊主编推荐的精彩文章快览，本期文章属“纳米领域”，英文点评来自英国皇家化学会期刊的主编。如果大家对我们的解读有更多的补充和点评，欢迎在文末写评论发表您的高见！

Chemical Science (IF: 9.556)

1. Accurate cancer cell identification and microRNA silencing induced therapy using tailored DNA tetrahedron nanostructures

Chem. Sci., 2019, Advance Article

DOI: 10.1039/C9SC04823E

Scientists from China report the first example of DNA tetrahedron nanostructures that display improved resistance to enzymatic digestion, high cellular uptake efficiency and are able to simultaneously monitor three intracellular miRNAs. The nanostructures not only effectively distinguish tumor cells from normal cells, but also identify cancer cell subtypes, which avoids false-positive signals and significantly improves the accuracy of cancer diagnosis. The nanostructures also hold potential as an anti-cancer drug.

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2. Single molecule sensing of amyloid-β aggregation by confined glass nanopores

Chem. Sci., 2019, Advance Article

DOI: 10.1039/C9SC03260F

Researchers from China have developed a glass nanopore based single molecule tool to investigate the dynamic oligomerization and aggregation process of Aβ1–42 peptides. The differences in molecular size and surface charge of amyloid aggregated states are distinguished through single molecule induced characteristic current fluctuation. The study reveals that the neurotoxic Aβ1–42 oligomer tends to adsorb onto the solid surface of nanopores, which may explain its instability and highly neurotoxic features.

Open Access（可免费阅读原文）

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Nanoscale Horizons (IF: 9.095)

1. Rich topologies of monolayer ices via unconventional electrowetting

Nanoscale Horiz., 2019, Advance Article

DOI: 10.1039/C9NH00619B

The notion of non-conventional electrowetting is proposed for the first time. By changing the electric field of dipoles or quadrupoles embedded in the model substrates, the wettability of the substrates can be tuned from superhydrophobic to superhydrophilic. At a threshold value, water droplets can completely spread over the model substrate at room temperature, giving the first evidence for breaking the contact-angle saturation limitation via non-conventional electrowetting. Rich topologies of monolayer ice can be obtained by changing the overall patterns of dipoles or quadrupoles on the substrate. Two new topologies of monolayer ices, namely, 4•62 and 4•6•12, were obtained: one stable below room temperature and the other stable at room temperature.

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2. Subnanometer iron clusters confined in a porous carbon matrix for highly efficient zinc–air batteries

Nanoscale Horiz., 2019, Advance Article

DOI: 10.1039/C9NH00510B

Constructing stable and resource-rich transition metal subcluster catalysts is difficult. This work demonstrates the potential of employing metal–organic frameworks to confine subclusters and achieve active ORR electrocatalysts. A facile synthetic protocol is presented to incorporate molecule-like Fe coordinates into a nitrogen-doped carbon matrix. The structure of Fe subclusters was revealed using X-ray absorption fine structure spectroscopy and density functional theory. The electrochemical behaviour of the Fe subclusters was superior to atomically-dispersed and nanoparticle Fe catalysts. These results have broad implications for the fundamental understanding of the active sites of subcluster catalysts at the atomic level.

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3. Developing substrate-based small molecule fluorescent probes for super-resolution fluorescent imaging of various membrane transporters

Nanoscale Horiz., 2019, Advance Article

DOI: 10.1039/ C9NH00596J

High-quality fluorescent imaging requires highly accurate labelling. To achieve this probes must efficiently and specifically deliver bright fluorophores into close proximity of the targeted molecules with a low background. Natural substrates are small and have high specificity to their specific transporters, so this work utilises select small substrates to recognize membrane transporters. The substrates were modified and coupled to a fluorescent dye with a PEG linker to form a small probe. Compared with traditional antibody probes the synthetic probes are quite small, which allows higher labelling density. Based on chemo-selectivity of an organic reaction, one substrate is coupled to only one organic dye, which is beneficial to more accurately display the distribution of targets. With this probe labelling, the organization of membrane transporters were characterized.

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