当前位置: X-MOL 学术Neuron › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Dynamics of Gut-Brain Communication Underlying Hunger.
Neuron ( IF 14.7 ) Pub Date : 2017-Oct-11 , DOI: 10.1016/j.neuron.2017.09.043
Lisa R. Beutler , Yiming Chen , Jamie S. Ahn , Yen-Chu Lin , Rachel A. Essner , Zachary A. Knight

Communication between the gut and brain is critical for homeostasis, but how this communication is represented in the dynamics of feeding circuits is unknown. Here we describe nutritional regulation of key neurons that control hunger in vivo. We show that intragastric nutrient infusion rapidly and durably inhibits hunger-promoting AgRP neurons in awake, behaving mice. This inhibition is proportional to the number of calories infused but surprisingly independent of macronutrient identity or nutritional state. We show that three gastrointestinal signals-serotonin, CCK, and PYY-are necessary or sufficient for these effects. In contrast, the hormone leptin has no acute effect on dynamics of these circuits or their sensory regulation but instead induces a slow modulation that develops over hours and is required for inhibition of feeding. These findings reveal how layers of visceral signals operating on distinct timescales converge on hypothalamic feeding circuits to generate a central representation of energy balance.

中文翻译:

饥饿背后的肠道-大脑沟通动力学。

肠与大脑之间的交流对于动态平衡至关重要,但是如何在饲喂回路的动力学中体现这种交流尚不清楚。在这里,我们描述了控制体内饥饿的关键神经元的营养调节。我们表明,在清醒状态下,老鼠体内的胃内营养素输注可以快速,持久地抑制促饥饿的AgRP神经元。这种抑制与所注入的卡路里数量成正比,但出乎意料地与常量营养素特性或营养状态无关。我们表明,三种胃肠道信号(血清素,CCK和PYY)对于这些作用是必要的或足够的。相反,激素瘦素对这些回路的动力学或其感觉调节没有急性作用,而是诱导缓慢的调节作用,该调节作用持续数小时,是抑制进食所必需的。
更新日期:2017-10-11
down
wechat
bug