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Base-Promoted Cascade C–C Coupling/N-α-sp3C–H Hydroxylation for the Regiospecific Synthesis of 3-Hydroxyisoindolinones
Organic Letters ( IF 4.9 ) Pub Date : 2017-09-12 00:00:00 , DOI: 10.1021/acs.orglett.7b02442 Jinhai Shen 1 , Qihua You 1 , Qi Fu 1 , Changsheng Kuai 2 , Huabin Huang 1 , Li Zhao 1 , Zhixia Zhuang 1
Organic Letters ( IF 4.9 ) Pub Date : 2017-09-12 00:00:00 , DOI: 10.1021/acs.orglett.7b02442 Jinhai Shen 1 , Qihua You 1 , Qi Fu 1 , Changsheng Kuai 2 , Huabin Huang 1 , Li Zhao 1 , Zhixia Zhuang 1
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A base-promoted cascade reaction for the regiospecific synthesis of substituted 3-hydroxyisoindolinones under transition-metal-free conditions is developed. The base-mediated C–C bond coupling and N-α-sp3C–H bond hydroxylation are involved in this procedure, which features high regioselectivity, efficiency, and environmental friendliness. Various substituted 3-hydroxyisoindolinones, including some bioactive molecules, were provided in up to 93% yield for 28 examples.
中文翻译：
碱促进级联C-C耦合/ Ñ -α-SP 3 C-H羟化3- Hydroxyisoindolinones的特异合成
开发了一种碱促进的级联反应，用于在无过渡金属的条件下区域特异性合成取代的3-羟基异吲哚满酮。的碱介导的C-C键偶联和Ñ -α-SP 3 C-H键羟化都参与了这一过程，其具有高的区域选择性，效率和环境友好性。对于28个实例，以高达93％的产率提供了包括一些生物活性分子的各种取代的3-羟基异吲哚啉酮。
更新日期：2017-09-12
中文翻译：
碱促进级联C-C耦合/ Ñ -α-SP 3 C-H羟化3- Hydroxyisoindolinones的特异合成
开发了一种碱促进的级联反应，用于在无过渡金属的条件下区域特异性合成取代的3-羟基异吲哚满酮。的碱介导的C-C键偶联和Ñ -α-SP 3 C-H键羟化都参与了这一过程，其具有高的区域选择性，效率和环境友好性。对于28个实例，以高达93％的产率提供了包括一些生物活性分子的各种取代的3-羟基异吲哚啉酮。
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