As a candidate for a rapid detection of biomaterials, terahertz (THz) spectroscopy system can be considered with some advantage in non-destructive, label-free, and non-contact manner. Because protein-ligand binding energy is in the THz range, especially, most important conformational information in molecular interactions can be captured by THz electromagnetic wave. Based on the THz time-domain spectroscopy system, THz nano-metamaterial sensing chips were prepared for great enhancing of detection sensitivity. A metamaterial sensing chip was designed for increasing of absorption cross section of the target sample, related to the transmitted THz near field enhancement via the composition of metamaterial. The measured THz optical properties were then analyzed in terms of refractive index and absorption coefficient, and compared with simulation results. Also, virus quantification regarding various concentrations of the viruses was performed, showing a clear linearity. The proposed sensitive and selective THz detection method can provide abundant information of detected biomaterials to help deep understanding of fundamental optical characteristics of them, suggesting rapid diagnosis way especially useful for such dangerous and time-sensitive target biomaterials.

中文翻译：

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用于超灵敏太赫兹生物传感的纳米超材料。

作为快速检测生物材料的候选人，太赫兹（THz）光谱系统可以以无损，无标签和非接触的方式被认为具有某些优势。特别是因为蛋白质-配体的结合能在THz范围内，所以在分子相互作用中最重要的构象信息可以通过THz电磁波捕获。在太赫兹时域光谱系统的基础上，制备了太赫兹纳米超材料感测芯片，以大大提高检测灵敏度。设计了一种超材料传感芯片，用于增加目标样品的吸收截面，这与通过超材料的成分传输的太赫兹近场增强有关。然后根据折射率和吸收系数分析测得的太赫兹光学性质，并与仿真结果进行比较。另外，对各种浓度的病毒进行了病毒定量，显示出明显的线性。提出的灵敏，选择性的太赫兹检测方法可以为被检测的生物材料提供丰富的信息，有助于对它们的基本光学特性的深刻理解，为快速，简便的诊断方法提供了依据。