PEGylated GdF3:Fe Nanoparticles as Multimodal T1/T2-Weighted MRI and X-ray CT Imaging Contrast Agents,ACS Applied Materials & Interfaces

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PEGylated GdF3:Fe Nanoparticles as Multimodal T1/T2-Weighted MRI and X-ray CT Imaging Contrast Agents
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2017-05-30 00:00:00 , DOI: 10.1021/acsami.7b04438
Lile Dong _{1,

2} , Peng Zhang ₃ , Pengpeng Lei _{1,

4} , Shuyan Song ₁ , Xia Xu _{1,

4} , Kaimin Du _{1,

2} , Jing Feng ₁ , Hongjie Zhang ₁

Affiliation

Contrast agents for multimodal imaging are in high demand for cancer diagnosis. To date, integration of T₁/T₂-weighted magnetic resonance imaging (MRI) and X-ray computed tomography (CT) imaging capabilities in one system to obtain an accurate diagnosis still remains challenging. In this work, biocompatible PEGylated GdF₃:Fe nanoparticles (PEG-GdF₃:Fe NPs) were reasonable designed and synthesized as multifunctional contrast agents for efficient T₁/T₂-weighted MRI and X-ray CT multimodal imaging. Owing to the enhanced permeability and retention effect in vivo, strong T₁ contrast, evident T₂ contrast, and X-ray CT signals in a tumor lesion can be observed after intravenous injection of PEG-GdF₃:Fe NPs. Therefore, PEG-GdF₃:Fe NPs could be used as potential multimodal contrast agents for cancer diagnosis.

中文翻译：

聚乙二醇化的GdF ₃：Fe纳米颗粒作为多峰T ₁ / T ₂加权MRI和X射线CT成像造影剂

对于多模态成像的造影剂在癌症诊断中有很高的需求。迄今为止，将T ₁ / T ₂加权磁共振成像（MRI）和X射线计算机断层扫描（CT）成像功能集成到一个系统中以获得准确的诊断仍然很困难。在这项工作中，合理设计并合成了生物相容性PEG化GdF ₃：Fe纳米颗粒（PEG-GdF ₃：Fe NPs）作为多功能造影剂，以进行有效的T ₁ / T ₂加权MRI和X射线CT多峰成像。由于增强的体内通透性和保留作用，强烈的T ₁对比明显静脉注射PEG-GdF ₃：Fe NPs后，可以观察到T ₂对比和肿瘤病变中的X射线CT信号。因此，PEG-GdF ₃：Fe NPs可以用作潜在的多峰造影剂进行癌症诊断。

更新日期：2017-06-09

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