近五年代表性成果
1. Lei X*, Mao S*, Li Y, Huang S, Li J, Du W, Kuang C, Yuan K#. ERVcancer: A web resource designed for querying human endogenous retrovirus activation across major cancer types. J Genet Genomics. 2024 Sep 10:S1673-8527(24)00241-8.
中南大学袁凯团队开发ERVcancer: 在线分析不同癌症中人类内源逆转录病毒的激活图谱
2. Tang R, Zhou M, Chen Y, Jiang Z, Fan X, Zhang J, Dong A, Lv L, Mao S, Chen F, Gao G, Min J, Liu K#, Yuan K#. H3K14ac facilitates the reinstallation of constitutive heterochromatin in Drosophila early embryos by engaging Eggless/SetDB1. Proc Natl Acad Sci. 2024 Aug 6; 121(33): e2321859121.
袁凯课题组与刘珂课题组合作在PNAS上发文揭示Eggless/SetDB1调控果蝇早期胚胎组成型异染色质建立的重要机制
3. Yu H, Liu D, Zhang Y, Tang R, Fan X, Mao S, Lv L, Chen F, Qin H, van Aalten D, Yang B, Yuan K#. Tissue-specific O-GlcNAcylation profiling identifies ribosomal substrates in Drosophila mushroom body critical for olfactory learning. eLife. 2024 Apr 15;13:e91269.
袁凯课题组利用O-GlcNAc糖基化蛋白富集鉴定新方法揭示果蝇认知功能调控新机制
4. Yang F, Ding M, Song X, Chen F, Yang T, Wang C, Hu C, Hu Q, Yao Y, Du S, Yao PY, Xia P, Adams G Jr, Fu C, Xiang S, Liu D, Wang Z#, Yuan K#, Liu X#. Organization of microtubule plus-end dynamics by phase separation in mitosis. J Mol Cell Biol. 2024 Jul 29;16(2):mjae006.
5. Liu H, Yu C, Zhang N#, Huang C, Wang Z, Lv L, Hu C, Chen F, Xiao Z, Zhang Z, Yuan K#. Transcriptional pausing induced by ionizing radiation enables the acquisition of radioresistance in nasopharyngeal carcinoma. J Mol Cell Biol. 2024 Jan 5;15(7):mjad044.
袁凯课题组发文揭示电离辐射诱导的转录暂停参与鼻咽癌放疗抵抗发生的新机制
6. Zhang Y, Yu H, Wang D, Lei X, Meng Y, Zhang N, Chen F, Lv L, Pan Q, Qin H, Zhang Z, van Aalten D#, Yuan K#. Protein O-GlcNAcylation homeostasis regulates facultative heterochromatin to fine-tune sog-Dpp signaling during Drosophila early embryogenesis. J Genet Genomics. 2023 Dec;50(12):948-959.
袁凯课题组发文揭示果蝇早期胚胎O-GlcNAc糖基化稳态参与调控神经发育的新机制
7. Yang J, Tang R, Chen S, Chen Y, Zhang L, Yuan K#, Huang R#, Wang L#. Exposure to high-sugar diet induces transgenerational changes in sweet sensitivity and feeding behavior via H3K27me3 reprogramming. eLife. 2023 Sep 12;12:e85365.
8. Li L*, Li Y*, Lv L, Yuan K#. Rewiring the transcriptional circuitries in cancer by endogenous retroviruses. J Mol Cell Biol. 2022 Dec 26;14(8):mjac053.
袁凯课题组在《Journal of Molecular Cell Biology》上发表短评
9. Li L*, Li P*, Chen J*, Li L, Shen Y, Zhu Y, Liu J, Lv L, Mao S, Chen F, Hu G, Yuan K#. Rif1 interacts with non-canonical polycomb repressive complex PRC1.6 to regulate mouse embryonic stem cell fate potential. Cell Regen. 2022 Aug 2;11(1):25.
袁凯课题组发文揭示Rif1和PRC1.6复合物共同参与胚胎干细胞命运潜能调控
10. Yu C*, Lei X*, Chen F, Mao S, Lv L, Liu H, Hu X, Wang R, Shen L, Zhang N, Meng Y, Shen Y, Chen J, Li P, Huang S, Lin C, Zhang Z, Yuan K#. ARID1A loss derepresses a group of human endogenous retrovirus-H loci to modulate BRD4-dependent transcription. Nat Commun.2022 Jun 17;13(1):3501.
袁凯课题组发文揭示抑癌基因ARID1A缺失通过激活内源性逆转录病毒元件HERVH调控肿瘤细胞基因转录的新机制
11. Yu H*, Li Y*, Li L*, Huang J, Wang X, Tang R, Jiang Z, Lv L, Chen F, Yu C, Yuan K#. Functional reciprocity of proteins involved in mitosis and endocytosis. FEBS J. 2021 Oct;288(20):5850-5866.
袁凯课题组在《FEBS Journal》发表综述对参与有丝分裂和内吞作用的关键蛋白进行总结与讨论
12. Strong I*, Lei X*, Chen F, Yuan K#, O’Farrell P. Interphase-arrested Drosophila embryos activate zygotic gene expression and initiate Mid-Blastula Transition events at a low nuclear-cytoplasmic ratio. PLoS Biol. 2020 Oct 22;18(10):e3000891.
袁凯课题组在《PLOS Biology》发文揭示触发早期胚胎合子基因组转录和中囊胚过渡的新模型
13. Tang R*, Jiang Z*, Chen F*, Yu W, Fan K, Tan J, Zhang Z, Liu X#, Li P, Yuan K#. The kinase activity of Drosophila BubR1 is required for insulin signaling-dependent stem cell maintenance. Cell Rep. 2020 Jun 23;31(12):107794.
中南大学袁凯课题组揭示有丝分裂检查点复合体核心成分BubR1在胰岛素信号通路中新功能
参编书籍
1.《发育生物学》（第二版），主编：王玉凤，2021，科学出版社，ISBN: 9787030696373.
2.《类器官及其应用》，主编：陈晔光、惠利健，2023，上海科学技术出版社，ISBN: 9787547863725.
专利申请
1. 袁凯，祁敏，张江林，张敬恒，李书瑶，李宗霖，许铭锐，谭潇阳，匡春梅，陈芳，吕露，毛松。一种小鼠皮肤伤口牵拉装置及方法。2024，中国，专利申请号：202410586232.3
2. 袁凯，刘虹璐，俞春红，张娜，孟阳，黄璨华，陈芳。CDK7抑制剂THZ1在鼻咽癌放疗抵抗治疗中的应用。2022，中国，专利申请号：202210090425.0
3. 袁凯，俞春红，雷晓云，邵豪，陈芳，毛松，吕露。靶向HERV-H的物质在肿瘤中的应用。2021，中国，专利号：ZL202110439495.8
4. 袁凯，丹尼尔.范.阿尔顿，张耀文，王丹丹，陈芳，孟阳，张娜，廖潇啸。一种动态检测蛋白质O-GlcNAc糖基化的探针及其制备方法与应用。2020，中国，专利申请号：202010837783.4
5. Yuan K, O’Farrell PH. Introducing fluorescent TALENT (TALE-based Nucleic Acid Tagging) – a method to stain specific DNA sequences, and its application in diagnosing disease-related genetic abnormalities. 2014，USA，申请号：SF2014-072.
6. 姚雪彪，王峰松，都建，丁霞，花沙沙，刘丹，金长江，蔡欣，袁凯。CENP-E结合蛋白及其编码基因在制备抑制肿瘤增殖药物中的应用。2011，中国，专利号：ZL200910132678.4
