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陈景 教授    

名:陈景

称:教授


E-mailjingchen3236@njucm.edu.cn

                                                                               

向:

1)中药递送微纳米载体

2)多功能可注射凝胶用于中药原位缓释

 

201710月博士毕业于苏州大学(导师:钟志远和邓超教授),20183月至20213月,在美国康奈尔大学开展博士后研究(合作导师:马明林教授),20215月以特聘教授引进南京中医药大学药学院工作。2022年入选江苏省特聘教授。自2021年起担任Acta Materia MedicaTraditional Medicine Research两本期刊青年编委。已在Nature Food Science Translational MedicineNature Communications, Advanced MaterialsActa Pharmaceutica Sinica B, Nano LettersBioactive MaterialsBiomaterials等权威杂志发表论文20篇,其中以第一作者或通讯作者(含共同)发表论文13篇,谷歌学术总引用1000余次。此外申请了2项中国专利和2项美国专利,授权中国专利2项,申请的一项美国专利已实现产业转化。曾获得2017 Baxter China Young Investigator Award一等奖。

 

1)     目,生物响应可逆交联的多功能透明质酸-聚肽纳米载体用于乳腺癌的靶向治疗,2015/01-2018/12 与,85万,结

2)     目,具双重靶向和穿膜性能的多功能纳米凝胶用于癌症的高效蛋白药物治疗,2018/01-2021/12 与,61万,结

3)     南京中医药大学校特聘教授科研基金,主持,40万,在研

4)     江苏省特聘教授基金,主持,200万,在研

 

 

1)     B. Wang#*, J. Chen#, J.S. Caserto#, X. Wang and M. Ma*. An in situ hydrogel-mediated chemo-immunometabolic cancer therapy. Nature Communications, 2022, 13(1): 1-13.

2)     J. Chen, J.S. Caserto, I. Ang, K. Shariati, J. Webb, B. Wang, X. Wang, N. Bouklas and M. Ma*. An adhesive and resilient hydrogel for the sealing and treatment of gastric perforation. Bioactive Materials, 2021, 14: 52-60.

3)     J. Chen#, B. Wang#*, J.S. Caserto, K. Shariati, P. Cao, Y. Pan, Q. Xu and M. Ma*. Sustained Delivery of SARS‐CoV‐2 RBD Subunit Vaccine using a High Affinity Injectable Hydrogel Scaffold. Advanced Healthcare Materials, 2021: 2101714.

4)     J. Chen, J. Webb, K. Shariati, S. Guo, J. K. Montclare, S. McArt, and M. Ma*. Pollen-mimicking, enzyme-loaded microparticles to reduce organophosphate toxicity in managed pollinators. Nature Food. 2021, 2, 339-347. (Cover of May issue)

5)     J. Chen, D. Wang, L. -H. Wang, W. Liu, A. Chiu, K. Shariati, Q. Liu, X. Wang, Z. Zhong, J. Webb, R. E. Schwartz, N. Bouklas and M. Ma*. An adhesive hydrogel with “load-sharing” effect as tissue bandages for drug and cell delivery. Advanced Materials. 2020, 2001628.

6)     J. Chen, H. He, C. Deng*, L. Yin and Z. Zhong*. Saporin-loaded CD44 and EGFR dual-targeted nanogels for potent inhibition of metastatic breast cancer in vivo. International Journal of Pharmaceutics, 2019, 560: 57-64.

7)     J. Chen, K. Huang, Q. Chen, C. Deng*, J. Zhang and Z. Zhong*. Tailor-making fluorescent hyaluronic acid microgels via combining microfluidics and photoclick chemistry for sustained and localized delivery of herceptin in tumors. ACS Applied Materials & Interfaces, 2018, 10(4): 3929-3937.

8)     J. Chen, J. Ouyang, Q. Chen, C. Deng*, F. Meng*, J. Zhang, R. Cheng, Q. Lan and Z. Zhong*. EGFR and CD44 dual-targeted multifunctional hyaluronic acid nanogels boost protein delivery to ovarian and breast cancers in vitro and in vivo. ACS Applied Materials & Interfaces, 2017, 9(28): 24140-24147.

9)     J. Chen, Y. Zou, C. Deng*, F. Meng, J. Zhang and Z. Zhong*. Targeted and potent cancer protein therapy using bioresponsive fluorescent click nanogels. Journal of Controlled Release, 2017, 259: e65.

10) J. Chen, Y. Zou, C. Deng*, F. Meng, J. Zhang and Z. Zhong*. Multifunctional click hyaluronic acid nanogels for targeted protein delivery and effective cancer treatment in vivo. Chemistry of Materials, 2016, 28(23): 8792-8799.

 

(授权专利)

1) 邓超,陈景,孟凤华,钟志远,一种抗肿瘤药物的制备方法,申请,2016. 07. 10 PCT/CN201610536411. 1

2) 邓超,陈景,孟凤华,钟志远,一种自发荧光纳米凝胶及其制备方法与应用,申请,2016. 07. 08CN201610536475.1