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成果及论文

1.Xiao FH*, Wang HT, Zhao L, Xia TR, Yang LQ, Ma SY, Kong QP*. Methylome analysis in long-lived men deciphers DNA methylation modifications associated with male longevity in humans. Cell Reports, 2025, In Press.

2.Xiao FH#, Wang HT#, Chen XQ, Ge MX, Yan D, Yang XL, Yang LQ, Lin R, Guo RH, Zhang W, Tang N, He Y, Zhou J, Cai WW*, Kong QP*. Hypermethylation in H3K9me3 regions characterizes the centenarian methylomes in healthy aging. National Science Review, 2023, 10:nwad067.

3.Xiao FH#, Yu Q#, Deng ZL#, Yang K, Ye Y, Ge MX, Yan D, Wang HT, Chen XQ, Yang LQ, Yang BY, Lin R, Zhang W, Yang XL, Dong L, He YH, Zhou J, Cai WW*, Li J*, Kong QP*. ETS1 acts as a regulator of human healthy aging via decreasing ribosomal activity. Science Advances, 2022, 8:eabf2017.

4.Wang HT, Zhao L, Yang LQ, Ge MX, Yang XL, Gao ZL, Cun YP*, Xiao FH*, Kong QP*. Scrutiny of genome-wide somatic mutation profiles in centenarians identifies the key genomic regions for human longevity. Aging Cell, 2024, 23:e13916.

5.Wang HT#Xiao FH#,*, Gao ZL, Guo LY, Yang LQ, Li GH, Kong QP*. Methylation entropy landscape of Chinese long-lived individuals reveals lower epigenetic noise related to human healthy aging. Aging Cell, 2024, 23:e14163.

6.Xiao FH#, Chen XQ#, Yu Q#, Ye Y#, Liu YW, Yan D, Yang LQ, Chen G, Lin R, Yang L, Liao X, Zhang W, Zhang W, Tang NLS, Wang XF, Zhou J*, Cai WW*, He YH*, Kong QP*. Transcriptome evidence reveals enhanced autophagy-lysosomal function in centenarians. Genome Research, 2018, 28:1601-1610. (Cover Story)

7.Xiao FH, Chen XQ, He YH, Kong QP. Accelerated DNA methylation changes in middle-aged men define sexual dimorphism in human lifespans. Clinical Epigenetics, 2018, 10:133.

8.Chen XQ, Zhang F, Su QC, Zeng C, Xiao FH*, Peng Y*. Methylome and transcriptome analyses reveal insights into the epigenetic basis for the good survival of hypomethylated ER-positive breast cancer subtype. Clinical Epigenetics, 2020, 12:16.

9.Xiao FH, Wang HT, Kong QP. Dynamic DNA methylation during aging: a "prophet" of age-related outcomes. Frontiers in Genetics, 2019, 10:107.

10.Xiao FH, Kong QP, Perry B, He YH. Progress on the role of DNA methylation in aging and longevity. Briefings in Functional Genomics, 2016, 15:454-459.

11.Xiao FH#, He YH#, Li QG, Wu H, Luo LH*, Kong QP*. A genome-wide scan reveals important roles of DNA methylation in human longevity by regulating age-related disease genes. PLoS One, 2015, 10:e0120388.

12.Chen XQ, Zhang F, Xiao FH*, Peng Y*. Deciphering the nexus between the tumor immune microenvironment and DNA methylation in subgrouping estrogen receptor-positive breast cancer. Breast Cancer, 2021, 28:1252-1260.

13.Aging Biomarker Consortium#, Bao H#, Cao J#, Chen M#, Chen M#, Chen W#, Chen X#, Chen Y#, Chen Y#, Chen Y#, Chen Z#, Chhetri JK#, Feng J#, Guo J#, Guo M#, He C#, Jia Y#, Jiang H#, Jing Y#, Li D#, Li J#, Li J#, Liang Q#, Liang R#, Liu F#, Liu X#, Liu Z#, Luo J#, Lv J#, Ma JY#, Mao K#, Nie J#, Qiao X#, Sun X#, Tang X#, Wang J#, Wang Q#, Wang S#, Wang X#, Wang Y#, Wu R#, Xia K#Xiao FH#, Xu L#, Xu Y#, Yan H#, Yang L#, Yang R#, Ying Y#, Zhang L#, Zhang W#, Zhang W#, Zhang X#, Zhang Z#, Zhou M#, Zhou R#, Zhu Q#, Zhu Z#, Cao F*, Cao Z*, Chan P*, Chen C*, Chen G*, Chen HZ*, Chen J*, Ci W*, Ding BS*, Ding Q*, Gao F*, Han JD*, Huang K*, Ju Z*, Kong Q*, Li J*, Li J*, Li X*, Liu B*, Liu L*, Liu Q*, Liu Q*, Liu X*, Liu Y*, Luo X*, Ma S*, Ma X*, Mao Z*, Nie J*, Peng Y*, Qu J*, Ren J*, Ren R*, Song M*, Songyang Z*, Sun YE*, Sun Y*, Tian M*, Wang SS*, Wang S*, Wang X*, Wang X*, Wang YJ*, Wang Y*, Wong C*, Xiang P*, Xiao Y*, Xie Z*, Xu D*, Ye J*, Yue R*, Zhang C*, Zhang H*, Zhang L*, Zhang W*, Zhang Y*, Zhang YW*, Zhang Z*, Zhao T*, Zhao Y*, Zhu D*, Zou W*, Pei G*, Liu GH*. Biomarkers of aging. Science China-Life Sciences, 2023, 66:893-1066.

14.Cai Y#, Song W#, Li J#, Jing Y#, Liang C#, Zhang L#, Zhang X#, Zhang W#, Liu B#, An Y#, Li J#, Tang B#, Pei S#, Wu X#, Liu Y#, Zhuang CL#, Ying Y#, Dou X#, Chen Y#Xiao FH#, Li D#, Yang R#, Zhao Y#, Wang Y#, Wang L#, Li Y#, Ma S*, Wang S*, Song X*, Ren J*, Zhang L*, Wang J*, Zhang W*, Xie Z*, Qu J*, Wang J*, Xiao Y*, Tian Y*, Wang G*, Hu P*, Ye J*, Sun Y*, Mao Z*, Kong QP*, Liu Q*, Zou W*, Tian XL*, Xiao ZX*, Liu Y*, Liu JP*, Song M*, Han JD*, Liu GH*. The landscape of aging. Science China-Life Sciences, 2022, 65:2354-2454.

15.Tang JX*, Xiao FH*. Editorial: The regulation of proteostasis in aging. Frontiers in Cell and Developmental Biology, 2023, 11:1221510.

16.Chen XQ#,*, Zhang X#, Pan DG#, Li GY, Hu RX, Wu T, Shen T, Cai XY, Cheng XS, Qin J, Xiao FH*, Li YF*. Identification of lncRNA-mRNA network linking ferroptosis and immune infiltration to colon adenocarcinoma suppression. Heliyon, 2024, 10:e33738.

17.Chen XQ#,*, Yang Q#, Chen WM#, Chen ZW, Guo GH, Zhang X, Sun XM, Shen T, Xiao FH*, Li YF*. Dual role of lysosome in cancer development and progression. Frontiers in Bioscience-Landmark, 2024, 29:393.

18.Yin FQ, Xiao FH*, Kong QP*. Factors involved in human healthy aging: insights from longevity individuals. Frontiers of Medicine, 2024, Accepted.

19.肖富辉,孔庆鹏*。人类健康增龄的发生机制——来自长寿人群的研究证据。中国医学前沿杂志(电子版)20241623-28。(专家述评)