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Baixing Wu is mainly engaged in the structural biology research of nucleic acid-related proteins using X-ray crystallography and Cryo-EM technology, combined with biochemical and molecular biology methods. Including: 1) Catalysis and recognition mechanism of RNA/DNA modification; 2) Structure and function of diseases-related and non-coding RNA biogenesis associated RNA-binding proteins; 3) The DNA replication and damage repair; 4) The metabolic mechanism of nucleoside-modified nucleic acids.