李玉行同学在Food Bioscience期刊发表题为“Synergistic modulation of chitosan on the mechanical and disintegration properties of pre-gelatinized waxy corn starch orally disintegrating film”的学术论文。

淀粉基口腔崩解膜（ODF）的机械性能良好但快速崩解特性是一大挑战。为了改善薄膜的机械和崩解性能，制备了壳聚糖/预糊化蜡质玉米淀粉口腔崩解膜，并对其物理性能、表面微观形态和结晶度进行了研究。结果表明，复合薄膜的机械性能得到改善（6.55 MPa±1.22 MPa，18.11%±2.34%），而同时快速崩解特性（<30 s）仍得以保持。在薄膜成型过程中，预糊化蜡质玉米淀粉链的老化受到壳聚糖分子的阻碍，增强了复合薄膜的可塑性和亲水性。壳聚糖和预糊化蜡质玉米淀粉之间存在协同作用。此外，显微图像表明，壳聚糖和预糊化蜡质玉米淀粉的高相容性使复合薄膜具有均匀的表面。然而，当壳聚糖浓度超过20%时，预糊化蜡质玉米淀粉会聚集，增加了复合薄膜中预糊化蜡质玉米淀粉的短程有序性和结晶度。该研究为开发具有良好机械性能和快速崩解特性的淀粉基ODF提供了理论依据。

原文链接：

https://doi.org/10.1016/j.fbio.2023.103317

原文摘要：

The inconsistency between good mechanical properties and rapid disintegration characteristic is a challenge for starch-based orally disintegrating films (ODF). In order to improve the mechanical and disintegration performances of the films, chitosan/pre-gelatinized waxy corn starch (PWCS) ODF was fabricated and investigated for physical properties, surface micromorphology and crystallinity. The results showed that the mechanical properties of the composite films were improved (6.55 MPa ± 1.22 MPa, 18.11% ± 2.34%) while the fast disintegration characteristic (<30 s) was still maintained. During the film-forming process, the retrogradation of PWCS chains was hindered by chitosan molecules and the polar groups were exposed, enhancing the plasticity and hydrophilicity of the composite films. There was a synergistic effect between chitosan and PWCS. In addition, the microscopic images indicated that the high compatibility of chitosan and PWCS caused a homogeneous surface for the composite films. However, PWCS aggregated when the concentration of chitosan exceeded 20%, which increased the short-range order and crystallinity of PWCS in the composite films. The study provided a theoretical feasibility for the development of novel oral carrier platform.